Several studies (see below) have demonstrated the therapeutic potential of hydrogen-rich saline in various conditions. Chen et al. (2010) showed that hydrogen-rich saline protects against spinal cord injury in rats by reducing oxidative stress and inflammation. Similarly, Chen et al. (2010) found that hydrogen-rich saline ameliorates the severity of acute pancreatitis in rats by mitigating oxidative damage. Hong et al. (2010) discussed the research advances in hydrogen therapy for nervous system diseases. Ren et al. (2012) and Ren et al. (2014) demonstrated the effectiveness of hydrogen-rich saline in reducing oxidative stress and inhibiting NLRP3 inflammasome activation in acute pancreatitis models. Additionally, studies by Wang et al. (2015) and Luo et al. (2015) highlighted the protective effects of hydrogen-rich saline in spinal cord injury and ischemia/reperfusion injury in pancreas grafts, respectively. Overall, these findings suggest the promising role of hydrogen therapy in mitigating tissue damage and inflammation in various pathological conditions.
538.Chen, C.W., et al., Hydrogen-Rich Saline Protects Against Spinal Cord Injury in Rats. Neurochemical Research, 2010. 35(7): p. 1111-1118.
539.Chen, H., et al., Hydrogen-rich saline ameliorates the severity of L-arginine-induced acute pancreatitis in rats. Biochem Biophys Res Commun, 2010. 393(2): p. 308-313.
540.Hong, Y., S. Chen, and J.M. Zhang, [Research advances on hydrogen therapy in nervous system diseases]. Zhejiang Da Xue Xue Bao Yi Xue Ban, 2010. 39(6): p. 638-43.
541.Ren, J., et al., Hydrogen-rich saline reduces the oxidative stress and relieves the severity of trauma-induced acute pancreatitis in rats. J Trauma Acute Care Surg, 2012. 72(6): p. 1555-61.
542.Ren, J.D., et al., Hydrogen-rich saline inhibits NLRP3 inflammasome activation and attenuates experimental acute pancreatitis in mice. Mediators Inflamm, 2014. 2014: p. 930894.
543.Zhang, D.Q. and J.H. Zhu, [Experimental studies of effects of hydrogen-rich saline in rats with severe acute pancreatitis]. Zhonghua Yi Xue Za Zhi, 2012. 92(34): p. 2436-40.
544.Zhang, D.Q., H. Feng, and W.C. Chen, Effects of hydrogen-rich saline on taurocholate-induced acute pancreatitis in rat. Evid Based Complement Alternat Med, 2013. 2013: p. 731932.
Chen, X., et al., Inhalation of Hydrogen of Different Concentrations Ameliorates Spinal Cord Injury in Mice by Protecting Spinal Cord Neurons from Apoptosis, Oxidative Injury and Mitochondrial Structure Damages. Cell Physiol Biochem, 2018. 47(1): p. 176-190.
Chen, L., et al., Hydrogen Treatment Protects Mice Against Chronic Pancreatitis by Restoring Regulatory T Cells Loss. Cell Physiol Biochem, 2017. 44(5): p. 2005-2016.
Zhou, H.X., et al., Protective Effects of Hydrogen Gas on Experimental Acute Pancreatitis. PLoS One, 2016. 11(4): p. e0154483.
Han, B., et al., MAPKs and Hsc70 are critical to the protective effect of molecular hydrogen during the early phase of acute pancreatitis. FEBS J, 2016. 283(4): p. 738-56.
Wang, J.L., et al., Hydrogen-rich saline injection into the subarachnoid cavity within 2 weeks promotes recovery after acute spinal cord injury. Neural Regen Res, 2015. 10(6): p. 958-64.
Shu, R.C., et al., Spinal peroxynitrite contributes to remifentanil-induced postoperative hyperalgesia via enhancement of divalent metal transporter 1 without iron-responsive element-mediated iron accumulation in rats. Anesthesiology, 2015. 122(4): p. 908-20.
Shi, Q., et al., Hydrogen-rich saline attenuates acute renal injury in sodium taurocholate-induced severe acute pancreatitis by inhibiting ROS and NF-kappaB pathway. Mediators Inflamm, 2015. 2015: p. 685043.
Luo, Z.L., et al., Hydrogen-Rich Saline Protects against Ischemia/Reperfusion Injury in Grafts after Pancreas Transplantations by Reducing Oxidative Stress in Rats. Mediators Inflamm, 2015. 2015: p. 281985.
Ren, J.D., et al., Hydrogen-rich saline inhibits NLRP3 inflammasome activation and attenuates experimental acute pancreatitis in mice. Mediators Inflamm, 2014. 2014: p. 930894.
Zhang, D.Q., H. Feng, and W.C. Chen, Effects of hydrogen-rich saline on taurocholate-induced acute pancreatitis in rat. Evid Based Complement Alternat Med, 2013. 2013: p. 731932.
Zhang, D.Q. and J.H. Zhu, [Experimental studies of effects of hydrogen-rich saline in rats with severe acute pancreatitis]. Zhonghua Yi Xue Za Zhi, 2012. 92(34): p. 2436-40.
Ren, J., et al., Hydrogen-rich saline reduces the oxidative stress and relieves the severity of trauma-induced acute pancreatitis in rats. J Trauma Acute Care Surg, 2012. 72(6): p. 1555-61.
Chen, H., et al., Hydrogen-rich saline ameliorates the severity of L-arginine-induced acute pancreatitis in rats. Biochem Biophys Res Commun, 2010. 393(2): p. 308-313.
Chen, C.W., et al., Hydrogen-Rich Saline Protects Against Spinal Cord Injury in Rats. Neurochemical Research, 2010. 35(7): p. 1111-1118.
