Hydrogen-rich water has been the subject of numerous research studies investigating its potential health benefits across various conditions. Here is a synopsis of some key research studies below and their findings on the effects of hydrogen-rich water:
- Positive effects of hydrogen-water bathing in patients with psoriasis and para psoriasis en plaques (Zhu, Q., et al., 2018) This study explored the benefits of hydrogen-water bathing in patients with skin conditions like psoriasis. The results showed positive effects of hydrogen-water bathing in alleviating symptoms and improving skin health.
- Hydrogen ameliorates oxidative stress in UVB-induced skin cells (Zhang, B., et al., 2018): The research focused on how hydrogen can reduce oxidative stress in skin cells exposed to UVB radiation through the PI3K-Akt signaling pathway. The findings suggested that hydrogen could help protect skin cells from UV-induced damage.
- Electrolytically generated hydrogen warm water promotes skin health (Tanaka, Y., et al., 2018): This study demonstrated that hydrogen-rich warm water could cleanse hair pores and enhance blood circulation in the skin more effectively than regular warm water. This could potentially benefit skin health and overall well-being.
- Effects of hydrogen-occluding-silica micro particles on wound repair (Li, Q., et al., 2018): The research investigated the effects of hydrogen-occluding-silica micro particles on wound healing and cell behaviour in oesophageal epithelial cells. The results indicated potential benefits for wound repair and cell migration.
- Hydrogen gas inhalation protects against cutaneous ischaemia/reperfusion injury (Fang, W., et al., 2018): This study explored how inhaling hydrogen gas could protect against skin injuries caused by ischemia/reperfusion. The findings suggested that hydrogen gas inhalation could be beneficial in preventing skin damage.
All the studies below collectively suggest that hydrogen-rich water may have positive effects on skin health, wound healing, oxidative stress reduction, and protection against radiation-induced damage.
Zhu, Q., et al., Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques. Sci Rep, 2018. 8(1): p. 8051.
Zhang, B., et al., Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells. Int J Mol Med, 2018. 41(6): p. 3653-3661.
Tanaka, Y., Y. Saitoh, and N. Miwa, Electrolytically generated hydrogen warm water cleanses the keratin-plug-clogged hair-pores and promotes the capillary blood-streams, more markedly than normal warm water does. Med Gas Res, 2018. 8(1): p. 12-18.
Li, Q., Y. Tanaka, and N. Miwa, Effects of hydrogen-occluding-silica microparticles on wound repair and cell migratory behavior of normal human esophageal epitheliocytes. . Medical Gas Research, 2018. 8(2): p. 57.
Fang, W., et al., Hydrogen gas inhalation protects against cutaneous ischaemia/reperfusion injury in a mouse model of pressure ulcer. J Cell Mol Med, 2018.
Zhang, J., et al., Hydrogen-Rich Water Ameliorates Total Body Irradiation-Induced Hematopoietic Stem Cell Injury by Reducing Hydroxyl Radical. Oxid Med Cell Longev, 2017. 2017: p. 8241678.
Yan, W.M., et al., The reason for the amelioration of N-methyl-N-nitrosourea-induced retinitis pigmentosa in rats by hydrogen-rich saline. Int J Ophthalmol, 2017. 10(10): p. 1495-1503.
Wu, C.Y., et al., Hydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes under oxidative stress. Sci Rep, 2017. 7(1): p. 3606.
Tamaki, N., et al., Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model. Oxid Med Cell Longev, 2016. 2016: p. 5679040.
Sawajiri, M., et al., Drinking high-energy electrolytic water decreases internal radiation exposure caused by the Fukushima Daiichi Nuclear power plant disaster Nuclear Technology & Radiation Protection, 2016. 31(2): p. 173-178.
Guo, J., et al., Protective Effects of Hydrogen against Low-Dose Long-Term Radiation-Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice. Oxid Med Cell Longev, 2016. 2016: p. 1947819.
Abou-Hamdan, M., et al., Molecular hydrogen attenuates radiation-induced nucleobase damage to DNA in aerated aqueous solutions. Int J Radiat Biol, 2016. 92(9): p. 536-41.
Xiao, Y.D., et al., Synergistic effect of hyperbaric oxygen preconditioning and hydrogen-rich saline in ameliorating rat flap ischemia/reperfusion injury. Plastic and Aesthetic Research, 2015. 2(6): p. 332.
Wang, X., et al., Hydrogen-rich saline resuscitation alleviates inflammation induced by severe burn with delayed resuscitation. Burns, 2015. 41(2): p. 379-85.
Liu, Y.Q., et al., Hydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway. Reconstructive & Aesthetic Surgery, 2015.
Ishibashi, T., et al., Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases. Mol Med Rep, 2015. 12(2): p. 2757-64.
Guo, S.X., et al., Beneficial effects of hydrogen-rich saline on early burn-wound progression in rats. PLoS One, 2015. 10(4): p. e0124897.
Zhao, S., et al., Protective effect of hydrogen-rich saline against radiation-induced immune dysfunction. J Cell Mol Med, 2014. 18(5): p. 938-46.
Yoon, Y.S., et al., Positive Effects of hydrogen water on 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice. Biol Pharm Bull, 2014. 37(9): p. 1480-5.
Mei, K., et al., Hydrogen protects rats from dermatitis caused by local radiation. J Dermatolog Treat, 2014. 25(2): p. 182-8.
Yu, W.T., et al., Hydrogen-enriched water restoration of impaired calcium propagation by arsenic in primary keratinocytes. Journal of Asian Earth Sciences, 2013. 77: p. 342-348.
Yang, Y., et al., Molecular hydrogen protects human lymphocyte AHH-1 cells against C heavy ion radiation. International Journal of Radiation Biology, 2013.
Shin, M.H., et al., Atomic Hydrogen Surrounded by Water Molecules, H(H2O)m, Modulates Basal and UV-Induced Gene Expressions in Human Skin In Vivo. PLoS One, 2013. 8(4): p. e61696.
Li, Q., et al., Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive effects on normal human skin cells in vitro. Med Gas Res, 2013. 3(1): p. 20.
Jiang, Z., et al., Protection by hydrogen against gamma ray-induced testicular damage in rats. Basic Clin Pharmacol Toxicol, 2013. 112(3): p. 186-91.
Ignacio, R.M., et al., The balneotherapy effect of hydrogen reduced water on UVB-mediated skin injury in hairless mice. Molecular & Cellular Toxicology, 2013. 9(1): p. 15-21.
Ignacio, R.M., et al., The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced by Dermatophagoides farinae Allergen in NC/Nga Mice. Evid Based Complement Alternat Med, 2013. 2013: p. 538673.
Yang, Y., et al., Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis. Med Sci Monit, 2012. 18(4): p. BR144-8.
Wei, L., et al., Hydrogen-rich saline protects retina against glutamate-induced excitotoxic injury in guinea pig. Experimental Eye Research, 2012. 94(1): p. 117-27.
Ono, H., et al., Hydrogen (H2) treatment for acute erythymatous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers. Medical Gas Research, 2012. 2(1): p. 14.
Kato, S., et al., Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes. J Photochem Photobiol B, 2012. 106: p. 24-33.
Guo, Z., et al., Hydrogen-rich saline protects against ultraviolet B radiation injury in rats. J Biomed Res, 2012. 26(5): p. 365-71.
Chuai, Y., et al., Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice. Med Sci Monit, 2012. 18(3): p. BR89-94.
Chuai, Y., et al., Hydrogen-rich saline attenuates radiation-induced male germ cell loss in mice through reducing hydroxyl radicals. Biochemical Journal, 2012. 442(1): p. 49-56.
Zhao, L., et al., Hydrogen protects mice from radiation induced thymic lymphoma in BALB/c mice. International Journal of Biological Sciences, 2011. 7(3): p. 297-300.
Yoon, K.S., et al., Histological study on the effect of electrolyzed reduced water-bathing on UVB radiation-induced skin injury in hairless mice. Biological and Pharmaceutical Bulletin, 2011. 34(11): p. 1671-7.
Qian, L.R., et al., Hydrogen-rich PBS protects cultured human cells from ionizing radiation-induced cellular damage. Nuclear Technology & Radiation Protection, 2010. 25(1): p. 23-29.
Qian, L.R., et al., Radioprotective effect of hydrogen in cultured cells and mice. Free Radic Res, 2010. 44(3): p. 275-282.
Kitamura, T., H. Todo, and K. Sugibayashi, Effect of several electrolyzed waters on the skin permeation of lidocaine, benzoic Acid, and isosorbide mononitrate. Drug Development and Industrial Pharmacy, 2009. 35(2): p. 145-53.
Zhu, Q., et al., Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques. Sci Rep, 2018. 8(1): p. 8051.
Zhang, B., et al., Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells. Int J Mol Med, 2018. 41(6): p. 3653-3661.
Tanaka, Y., Y. Saitoh, and N. Miwa, Electrolytically generated hydrogen warm water cleanses the keratin-plug-clogged hair-pores and promotes the capillary blood-streams, more markedly than normal warm water does. Med Gas Res, 2018. 8(1): p. 12-18.
Li, Q., Y. Tanaka, and N. Miwa, Effects of hydrogen-occluding-silica microparticles on wound repair and cell migratory behavior of normal human esophageal epitheliocytes. . Medical Gas Research, 2018. 8(2): p. 57.
Fang, W., et al., Hydrogen gas inhalation protects against cutaneous ischaemia/reperfusion injury in a mouse model of pressure ulcer. J Cell Mol Med, 2018.
Zhang, J., et al., Hydrogen-Rich Water Ameliorates Total Body Irradiation-Induced Hematopoietic Stem Cell Injury by Reducing Hydroxyl Radical. Oxid Med Cell Longev, 2017. 2017: p. 8241678.
Yan, W.M., et al., The reason for the amelioration of N-methyl-N-nitrosourea-induced retinitis pigmentosa in rats by hydrogen-rich saline. Int J Ophthalmol, 2017. 10(10): p. 1495-1503.
Wu, C.Y., et al., Hydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes under oxidative stress. Sci Rep, 2017. 7(1): p. 3606.
Tamaki, N., et al., Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model. Oxid Med Cell Longev, 2016. 2016: p. 5679040.
Sawajiri, M., et al., Drinking high-energy electrolytic water decreases internal radiation exposure caused by the Fukushima Daiichi Nuclear power plant disaster Nuclear Technology & Radiation Protection, 2016. 31(2): p. 173-178.
Guo, J., et al., Protective Effects of Hydrogen against Low-Dose Long-Term Radiation-Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice. Oxid Med Cell Longev, 2016. 2016: p. 1947819.
Abou-Hamdan, M., et al., Molecular hydrogen attenuates radiation-induced nucleobase damage to DNA in aerated aqueous solutions. Int J Radiat Biol, 2016. 92(9): p. 536-41.
Xiao, Y.D., et al., Synergistic effect of hyperbaric oxygen preconditioning and hydrogen-rich saline in ameliorating rat flap ischemia/reperfusion injury. Plastic and Aesthetic Research, 2015. 2(6): p. 332.
Wang, X., et al., Hydrogen-rich saline resuscitation alleviates inflammation induced by severe burn with delayed resuscitation. Burns, 2015. 41(2): p. 379-85.
Liu, Y.Q., et al., Hydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway. Reconstructive & Aesthetic Surgery, 2015.
Ishibashi, T., et al., Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases. Mol Med Rep, 2015. 12(2): p. 2757-64.
Guo, S.X., et al., Beneficial effects of hydrogen-rich saline on early burn-wound progression in rats. PLoS One, 2015. 10(4): p. e0124897.
Zhao, S., et al., Protective effect of hydrogen-rich saline against radiation-induced immune dysfunction. J Cell Mol Med, 2014. 18(5): p. 938-46.
Yoon, Y.S., et al., Positive Effects of hydrogen water on 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice. Biol Pharm Bull, 2014. 37(9): p. 1480-5.
Mei, K., et al., Hydrogen protects rats from dermatitis caused by local radiation. J Dermatolog Treat, 2014. 25(2): p. 182-8.
Yu, W.T., et al., Hydrogen-enriched water restoration of impaired calcium propagation by arsenic in primary keratinocytes. Journal of Asian Earth Sciences, 2013. 77: p. 342-348.
Yang, Y., et al., Molecular hydrogen protects human lymphocyte AHH-1 cells against C heavy ion radiation. International Journal of Radiation Biology, 2013.
Shin, M.H., et al., Atomic Hydrogen Surrounded by Water Molecules, H(H2O)m, Modulates Basal and UV-Induced Gene Expressions in Human Skin In Vivo. PLoS One, 2013. 8(4): p. e61696.
Li, Q., et al., Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive effects on normal human skin cells in vitro. Med Gas Res, 2013. 3(1): p. 20.
Jiang, Z., et al., Protection by hydrogen against gamma ray-induced testicular damage in rats. Basic Clin Pharmacol Toxicol, 2013. 112(3): p. 186-91.
Ignacio, R.M., et al., The balneotherapy effect of hydrogen reduced water on UVB-mediated skin injury in hairless mice. Molecular & Cellular Toxicology, 2013. 9(1): p. 15-21.
Ignacio, R.M., et al., The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced by Dermatophagoides farinae Allergen in NC/Nga Mice. Evid Based Complement Alternat Med, 2013. 2013: p. 538673.
Yang, Y., et al., Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis. Med Sci Monit, 2012. 18(4): p. BR144-8.
Wei, L., et al., Hydrogen-rich saline protects retina against glutamate-induced excitotoxic injury in guinea pig. Experimental Eye Research, 2012. 94(1): p. 117-27.
Ono, H., et al., Hydrogen (H2) treatment for acute erythymatous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers. Medical Gas Research, 2012. 2(1): p. 14.
Kato, S., et al., Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes. J Photochem Photobiol B, 2012. 106: p. 24-33.
Guo, Z., et al., Hydrogen-rich saline protects against ultraviolet B radiation injury in rats. J Biomed Res, 2012. 26(5): p. 365-71.
Chuai, Y., et al., Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice. Med Sci Monit, 2012. 18(3): p. BR89-94.
Chuai, Y., et al., Hydrogen-rich saline attenuates radiation-induced male germ cell loss in mice through reducing hydroxyl radicals. Biochemical Journal, 2012. 442(1): p. 49-56.
Zhao, L., et al., Hydrogen protects mice from radiation induced thymic lymphoma in BALB/c mice. International Journal of Biological Sciences, 2011. 7(3): p. 297-300.
Yoon, K.S., et al., Histological study on the effect of electrolyzed reduced water-bathing on UVB radiation-induced skin injury in hairless mice. Biological and Pharmaceutical Bulletin, 2011. 34(11): p. 1671-7.
Qian, L.R., et al., Hydrogen-rich PBS protects cultured human cells from ionizing radiation-induced cellular damage. Nuclear Technology & Radiation Protection, 2010. 25(1): p. 23-29.
Qian, L.R., et al., Radioprotective effect of hydrogen in cultured cells and mice. Free Radic Res, 2010. 44(3): p. 275-282.
Kitamura, T., H. Todo, and K. Sugibayashi, Effect of several electrolyzed waters on the skin permeation of lidocaine, benzoic Acid, and isosorbide mononitrate. Drug Development and Industrial Pharmacy, 2009. 35(2): p. 145-53.