Hydrogen Therapy | Skin & Radiance Article

Hydrogen-rich water has been the subject of numerous research studies investigating its potential health benefits across various conditions. Here is a synopsis of some key research studies below and their findings on the effects of hydrogen-rich water:

Positive effects of hydrogen-water bathing in patients with psoriasis and para psoriasis en plaques (Zhu, Q., et al., 2018) This study explored the benefits of hydrogen-water bathing in patients with skin conditions like psoriasis. The results showed positive effects of hydrogen-water bathing in alleviating symptoms and improving skin health.

Hydrogen ameliorates oxidative stress in UVB-induced skin cells (Zhang, B., et al., 2018): The research focused on how hydrogen can reduce oxidative stress in skin cells exposed to UVB radiation through the PI3K-Akt signaling pathway. The findings suggested that hydrogen could help protect skin cells from UV-induced damage.

Electrolytically generated hydrogen warm water promotes skin health (Tanaka, Y., et al., 2018): This study demonstrated that hydrogen-rich warm water could cleanse hair pores and enhance blood circulation in the skin more effectively than regular warm water. This could potentially benefit skin health and overall well-being.

Effects of hydrogen-occluding-silica micro particles on wound repair (Li, Q., et al., 2018): The research investigated the effects of hydrogen-occluding-silica micro particles on wound healing and cell behaviour in oesophageal epithelial cells. The results indicated potential benefits for wound repair and cell migration.

Hydrogen gas inhalation protects against cutaneous ischaemia/reperfusion injury (Fang, W., et al., 2018): This study explored how inhaling hydrogen gas could protect against skin injuries caused by ischemia/reperfusion. The findings suggested that hydrogen gas inhalation could be beneficial in preventing skin damage.

All the studies below collectively suggest that hydrogen-rich water may have positive effects on skin health, wound healing, oxidative stress reduction, and protection against radiation-induced damage.

Zhu, Q., et al., Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques. Sci Rep, 2018. 8(1): p. 8051.

Zhang, B., et al., Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells. Int J Mol Med, 2018. 41(6): p. 3653-3661.

Tanaka, Y., Y. Saitoh, and N. Miwa, Electrolytically generated hydrogen warm water cleanses the keratin-plug-clogged hair-pores and promotes the capillary blood-streams, more markedly than normal warm water does. Med Gas Res, 2018. 8(1): p. 12-18.

Li, Q., Y. Tanaka, and N. Miwa, Effects of hydrogen-occluding-silica microparticles on wound repair and cell migratory behavior of normal human esophageal epitheliocytes. . Medical Gas Research, 2018. 8(2): p. 57.

Fang, W., et al., Hydrogen gas inhalation protects against cutaneous ischaemia/reperfusion injury in a mouse model of pressure ulcer. J Cell Mol Med, 2018.

Zhang, J., et al., Hydrogen-Rich Water Ameliorates Total Body Irradiation-Induced Hematopoietic Stem Cell Injury by Reducing Hydroxyl Radical. Oxid Med Cell Longev, 2017. 2017: p. 8241678.

Yan, W.M., et al., The reason for the amelioration of N-methyl-N-nitrosourea-induced retinitis pigmentosa in rats by hydrogen-rich saline. Int J Ophthalmol, 2017. 10(10): p. 1495-1503.

Wu, C.Y., et al., Hydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes under oxidative stress. Sci Rep, 2017. 7(1): p. 3606.

Tamaki, N., et al., Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model. Oxid Med Cell Longev, 2016. 2016: p. 5679040.

Sawajiri, M., et al., Drinking high-energy electrolytic water decreases internal radiation exposure caused by the Fukushima Daiichi Nuclear power plant disaster Nuclear Technology & Radiation Protection, 2016. 31(2): p. 173-178.

Guo, J., et al., Protective Effects of Hydrogen against Low-Dose Long-Term Radiation-Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice. Oxid Med Cell Longev, 2016. 2016: p. 1947819.

Abou-Hamdan, M., et al., Molecular hydrogen attenuates radiation-induced nucleobase damage to DNA in aerated aqueous solutions. Int J Radiat Biol, 2016. 92(9): p. 536-41.

Xiao, Y.D., et al., Synergistic effect of hyperbaric oxygen preconditioning and hydrogen-rich saline in ameliorating rat flap ischemia/reperfusion injury. Plastic and Aesthetic Research, 2015. 2(6): p. 332.

Wang, X., et al., Hydrogen-rich saline resuscitation alleviates inflammation induced by severe burn with delayed resuscitation. Burns, 2015. 41(2): p. 379-85.

Liu, Y.Q., et al., Hydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway. Reconstructive & Aesthetic Surgery, 2015.

Ishibashi, T., et al., Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases. Mol Med Rep, 2015. 12(2): p. 2757-64.

Guo, S.X., et al., Beneficial effects of hydrogen-rich saline on early burn-wound progression in rats. PLoS One, 2015. 10(4): p. e0124897.

Zhao, S., et al., Protective effect of hydrogen-rich saline against radiation-induced immune dysfunction. J Cell Mol Med, 2014. 18(5): p. 938-46.

Yoon, Y.S., et al., Positive Effects of hydrogen water on 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice. Biol Pharm Bull, 2014. 37(9): p. 1480-5.

Mei, K., et al., Hydrogen protects rats from dermatitis caused by local radiation. J Dermatolog Treat, 2014. 25(2): p. 182-8.

Yu, W.T., et al., Hydrogen-enriched water restoration of impaired calcium propagation by arsenic in primary keratinocytes. Journal of Asian Earth Sciences, 2013. 77: p. 342-348.

Yang, Y., et al., Molecular hydrogen protects human lymphocyte AHH-1 cells against C heavy ion radiation. International Journal of Radiation Biology, 2013.

Shin, M.H., et al., Atomic Hydrogen Surrounded by Water Molecules, H(H2O)m, Modulates Basal and UV-Induced Gene Expressions in Human Skin In Vivo. PLoS One, 2013. 8(4): p. e61696.

Li, Q., et al., Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive effects on normal human skin cells in vitro. Med Gas Res, 2013. 3(1): p. 20.

Jiang, Z., et al., Protection by hydrogen against gamma ray-induced testicular damage in rats. Basic Clin Pharmacol Toxicol, 2013. 112(3): p. 186-91.

Ignacio, R.M., et al., The balneotherapy effect of hydrogen reduced water on UVB-mediated skin injury in hairless mice. Molecular & Cellular Toxicology, 2013. 9(1): p. 15-21.

Ignacio, R.M., et al., The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced by Dermatophagoides farinae Allergen in NC/Nga Mice. Evid Based Complement Alternat Med, 2013. 2013: p. 538673.

Yang, Y., et al., Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis. Med Sci Monit, 2012. 18(4): p. BR144-8.

Wei, L., et al., Hydrogen-rich saline protects retina against glutamate-induced excitotoxic injury in guinea pig. Experimental Eye Research, 2012. 94(1): p. 117-27.

Ono, H., et al., Hydrogen (H2) treatment for acute erythymatous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers. Medical Gas Research, 2012. 2(1): p. 14.

Kato, S., et al., Hydrogen-rich electrolyzed warm water represses wrinkle formation against UVA ray together with type-I collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes. J Photochem Photobiol B, 2012. 106: p. 24-33.

Guo, Z., et al., Hydrogen-rich saline protects against ultraviolet B radiation injury in rats. J Biomed Res, 2012. 26(5): p. 365-71.

Chuai, Y., et al., Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice. Med Sci Monit, 2012. 18(3): p. BR89-94.

Chuai, Y., et al., Hydrogen-rich saline attenuates radiation-induced male germ cell loss in mice through reducing hydroxyl radicals. Biochemical Journal, 2012. 442(1): p. 49-56.

Zhao, L., et al., Hydrogen protects mice from radiation induced thymic lymphoma in BALB/c mice. International Journal of Biological Sciences, 2011. 7(3): p. 297-300.

Yoon, K.S., et al., Histological study on the effect of electrolyzed reduced water-bathing on UVB radiation-induced skin injury in hairless mice. Biological and Pharmaceutical Bulletin, 2011. 34(11): p. 1671-7.

Qian, L.R., et al., Hydrogen-rich PBS protects cultured human cells from ionizing radiation-induced cellular damage. Nuclear Technology & Radiation Protection, 2010. 25(1): p. 23-29.

Qian, L.R., et al., Radioprotective effect of hydrogen in cultured cells and mice. Free Radic Res, 2010. 44(3): p. 275-282.

Kitamura, T., H. Todo, and K. Sugibayashi, Effect of several electrolyzed waters on the skin permeation of lidocaine, benzoic Acid, and isosorbide mononitrate. Drug Development and Industrial Pharmacy, 2009. 35(2): p. 145-53.