This research compilation explores the therapeutic potential of molecular hydrogen in various gastrointestinal conditions and inflammatory diseases. Studies investigate the effects of hydrogen-rich solutions on conditions such as ulcerative colitis, stress-induced gastric ulceration, sepsis, necrotizing enterocolitis, and intestinal ischemia-reperfusion injury. The research delves into the mechanisms through which hydrogen gas exerts its protective effects, including reducing oxidative stress, modulating inflammatory responses, promoting heme oxygenase-1 expression, and ameliorating endothelial dysfunction. Additionally, the studies highlight the role of molecular hydrogen in preserving intestinal grafts during transplantation, inhibiting aspirin-induced gastric mucosal injury, and enhancing gut microbiota health. Overall, the findings suggest that hydrogen therapy may hold promise as a novel and effective approach for managing a range of gastrointestinal and inflammatory disorders.

492.Anami, S., K. Saegusa, and M. Nishikata, Effect of glutamine or alkaline ionized water on late diarrhea induced by irinotecan hydrochloride in Gunn rats. . Asian Journal of Pharmaceutical Sciences, 2009. 4(2): p. 96-105.

493.Buchholz, B.M., et al., Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. Am J Transplant, 2008. 8(10): p. 2015-2024.

494.Buchholz, B.M., et al., Hydrogen-enriched preservation protects the isogeneic intestinal graft and amends recipient gastric function during transplantation. Transplantation, 2011. 92(9): p. 985-92.

495.Chen, H.G., et al., Heme oxygenase-1 mediates the anti-inflammatory effect of molecular hydrogen in LPS-stimulated RAW 264.7 macrophages. Int J Surg, 2013. 11(10): p. 1060-6.

496.He, J., et al., Protective effects of hydrogen-rich saline on ulcerative colitis rat model. Journal of Surgical Research, 2013(0).

497.Jin, D.K., Dong-Heui ; Teng, Yung-Chien ; Xufeng, Qi ; Lee, Kyu-Jae The Effect of Mineral-induced Alkaline Reduced Water on the DSS-induced Acute inflammatory Bowel Disease Mouse Model. Korean Journal of Microscopy, 2008. 38(2): p. 81-87.

498.Jin, Y., et al., Hydrogen May Be Used as a Treatment for Stress-Induced Gastric Ulceration. Med. Hypotheses Res, 2011. 7: p. 43-47.

499.Kajiya, M., et al., Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate. Biochem Biophys Res Commun, 2009: p. in press.

500.Li, G.M., et al., Effects of hydrogen-rich saline treatment on polymicrobial sepsis. Journal of Surgical Research, 2013. 181(2): p. 279-86.

501.Liu, X., et al., The protective of hydrogen on stress-induced gastric ulceration. Int Immunopharmacol, 2012. 13(2): p. 197-203.

502.McCarty, M.F., Potential ghrelin-mediated benefits and risks of hydrogen water. Med Hypotheses, 2015. 84(4): p. 350-5.

503.Naito, Y., et al., Chronic administration with electrolyzed alkaline water inhibits aspirin-induced gastric mucosal injury in rats through the inhibition of tumor necrosis factor-alpha expression. Journal of Clinical Biochemistry and Nutrition, 2002. 32: p. 69-81.

504.Nishimura, N., et al., Colonic hydrogen generated from fructan diffuses into the abdominal cavity and reduces adipose mRNA abundance of cytokines in rats. J Nutr, 2013. 143(12): p. 1943-9.

505.Pilcher, J.E., Senn on the Diagnosis of Gastro-Intestinal Perforation by the Rectal Insufflation of Hydrogen Gas. Annals of Surgery, 1888. 8(3): p. 190-204.

506.Senn, N., RECTAL INSUFFLATION OF HYDROGEN GAS AN INFALLIBLE TEST IN THE DIAGNOSIS OF VISCERAL INJURY OF THE GASTRO INTESTINAL CANAL IN PENETRATING WOUNDS OF THE ABDOMEN. Read in the Section on Surgery, at the Thirty-ninth Annual Meeting of the American Medical Association, May, 9, 1888, and illuistrated by three experiments on dogs.”. JAMA: Journal of the American Medical Association, 1888. 10(25): p. 767-777.

507.Sheng, Q., et al., Protective effects of hydrogen-rich saline on necrotizing enterocolitis in neonatal rats. J Pediatr Surg, 2013. 48(8): p. 1697-706.

508.Shigeta, T., et al., Luminal injection of hydrogen-rich solution attenuates intestinal ischemia-reperfusion injury in rats. Transplantation, 2015. 99(3): p. 500-7.

509.Vorobjeva, N.V., Selective stimulation of the growth of anaerobic microflora in the human intestinal tract by electrolyzed reducing water. Med Hypotheses, 2005. 64(3): p. 543-6.

510.Xie, K.L., et al., [Effects of hydrogen gas inhalation on serum high mobility group box 1 levels in severe septic mice]. Zhejiang Da Xue Xue Bao Yi Xue Ban, 2010. 39(5): p. 454-7.

511.Xie, K.L., et al., Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release. Shock, 2010. 34(1): p. 90-97.

512.Xie, K., et al., Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis. Shock, 2012. 38(6): p. 656-63.

513.Xie, K., et al., Nrf2 is critical in the protective role of hydrogen gas against murine polymicrobial sepsis. British Journal of Anaesthesia, 2012. 108(3): p. 538-539.

514.Xie, K., et al., Hydrogen gas presents a promising therapeutic strategy for sepsis. Biomed Res Int, 2014. 2014: p. 807635.

515.Xue, J., et al., Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water. BMC Complementary and Alternative Medicine, 2014. 14(1): p. 81.

516.Zhang, J.Y., et al., Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats. World J Gastroenterol, 2014. 20(6): p. 1614-22.

Zheng, W., et al., Intestinal Microbiota Ecological Response to Oral Administrations of Hydrogen-Rich Water and Lactulose in Female Piglets Fed a Fusarium Toxin-Contaminated Diet. Toxins (Basel), 2018. 10(6).

Xiao, H.W., et al., Hydrogen-water ameliorates radiation-induced gastrointestinal toxicity via MyD88’s effects on the gut microbiota. Exp Mol Med, 2018. 50(1): p. e433.

Nishimura, N., et al., Transplantation of High Hydrogen-Producing Microbiota Leads to Generation of Large Amounts of Colonic Hydrogen in Recipient Rats Fed High Amylose Maize Starch. Nutrients, 2018. 10(2).

Nakano, T., et al., Effect of molecular hydrogen on uterine inflammation during preterm labour. Biomed Rep, 2018. 8(5): p. 454-460.

Higashimura, Y., et al., Effects of molecular hydrogen-dissolved alkaline electrolyzed water on intestinal environment in mice. Med Gas Res, 2018. 8(1): p. 6-11.

Franceschelli, S., et al., Modulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of rich water molecular hydrogen: A new biological vision. J Cell Mol Med, 2018. 22(5): p. 2750-2759.

Wu, M.J., et al., Protective effects of hydrogen rich water on the intestinal ischemia/reperfusion injury due to intestinal intussusception in a rat model. Med Gas Res, 2017. 7(2): p. 101-106.

Shen, N.Y., et al., Hydrogen-rich water protects against in fl ammatory bowel disease in mice by inhibiting endoplasmic reticulum stress and promoting heme oxygenase-1 expression. World J Gastroenterol, 2017. 23(8): p. 1375-1386.

Ono, H., et al., Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection. J Stroke Cerebrovasc Dis, 2017.

Zheng, Y. and D. Zhu, Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis. Oxid Med Cell Longev, 2016. 2016: p. 5806057.

Liu, L.D., et al., Protective effect and mechanism of hydrogen treatment on lung epithelial barrier dysfunction in rats with sepsis. Genet Mol Res, 2016. 15(1).

Tao, B., et al., Hydrogen-Rich Saline Attenuates Lipopolysaccharide-Induced Heart Dysfunction by Restoring Fatty Acid Oxidation in Rats by Mitigating C-Jun N-Terminal Kinase Activation. Shock, 2015. 44(6): p. 593-600.

Shigeta, T., et al., Luminal injection of hydrogen-rich solution attenuates intestinal ischemia-reperfusion injury in rats. Transplantation, 2015. 99(3): p. 500-7.

Chen, H., et al., Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2/HO-1 signaling pathway. Int Immunopharmacol, 2015. 28(1): p. 643-54.

Zhang, J.Y., et al., Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats. World J Gastroenterol, 2014. 20(6): p. 1614-22.

Xue, J., et al., Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water. BMC Complementary and Alternative Medicine, 2014. 14(1): p. 81.

Xie, K., et al., Hydrogen gas presents a promising therapeutic strategy for sepsis. Biomed Res Int, 2014. 2014: p. 807635.

Sheng, Q., et al., Protective effects of hydrogen-rich saline on necrotizing enterocolitis in neonatal rats. J Pediatr Surg, 2013. 48(8): p. 1697-706.

Nishimura, N., et al., Colonic hydrogen generated from fructan diffuses into the abdominal cavity and reduces adipose mRNA abundance of cytokines in rats. J Nutr, 2013. 143(12): p. 1943-9.

Li, G.M., et al., Effects of hydrogen-rich saline treatment on polymicrobial sepsis. Journal of Surgical Research, 2013. 181(2): p. 279-86.

He, J., et al., Protective effects of hydrogen-rich saline on ulcerative colitis rat model. Journal of Surgical Research, 2013(0).

Chen, H.G., et al., Heme oxygenase-1 mediates the anti-inflammatory effect of molecular hydrogen in LPS-stimulated RAW 264.7 macrophages. Int J Surg, 2013. 11(10): p. 1060-6.

Xie, K., et al., Nrf2 is critical in the protective role of hydrogen gas against murine polymicrobial sepsis. British Journal of Anaesthesia, 2012. 108(3): p. 538-539.

Xie, K., et al., Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis. Shock, 2012. 38(6): p. 656-63.

Liu, X., et al., The protective of hydrogen on stress-induced gastric ulceration. Int Immunopharmacol, 2012. 13(2): p. 197-203.

Jin, Y., et al., Hydrogen May Be Used as a Treatment for Stress-Induced Gastric Ulceration. Hypotheses Res, 2011. 7: p. 43-47.

Buchholz, B.M., et al., Hydrogen-enriched preservation protects the isogeneic intestinal graft and amends recipient gastric function during transplantation. Transplantation, 2011. 92(9): p. 985-92.

Xie, K.L., et al., Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release. Shock, 2010. 34(1): p. 90-97.

Xie, K.L., et al., [Effects of hydrogen gas inhalation on serum high mobility group box 1 levels in severe septic mice]. Zhejiang Da Xue Xue Bao Yi Xue Ban, 2010. 39(5): p. 454-7.

Kajiya, M., et al., Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate. Biochem Biophys Res Commun, 2009: p. in press.

Anami, S., K. Saegusa, and M. Nishikata, Effect of glutamine or alkaline ionized water on late diarrhea induced by irinotecan hydrochloride in Gunn rats. . Asian Journal of Pharmaceutical Sciences, 2009. 4(2): p. 96-105.

Jin, D.K., Dong-Heui ; Teng, Yung-Chien ; Xufeng, Qi ; Lee, Kyu-Jae The Effect of Mineral-induced Alkaline Reduced Water on the DSS-induced Acute inflammatory Bowel Disease Mouse Model. Korean Journal of Microscopy, 2008. 38(2): p. 81-87.

Buchholz, B.M., et al., Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury. Am J Transplant, 2008. 8(10): p. 2015-2024.

Vorobjeva, N.V., Selective stimulation of the growth of anaerobic microflora in the human intestinal tract by electrolyzed reducing water. Med Hypotheses, 2005. 64(3): p. 543-6.

Naito, Y., et al., Chronic administration with electrolyzed alkaline water inhibits aspirin-induced gastric mucosal injury in rats through the inhibition of tumor necrosis factor-alpha expression. Journal of Clinical Biochemistry and Nutrition, 2002. 32: p. 69-81.

Senn, N., RECTAL INSUFFLATION OF HYDROGEN GAS AN INFALLIBLE TEST IN THE DIAGNOSIS OF VISCERAL INJURY OF THE GASTRO INTESTINAL CANAL IN PENETRATING WOUNDS OF THE ABDOMEN. Read in the Section on Surgery, at the Thirty-ninth Annual Meeting of the American Medical Association, May, 9, 1888, and illustrated by three experiments on dogs.”. JAMA: Journal of the American Medical Association, 1888. 10(25): p. 767-777.

Pilcher, J.E., Senn on the Diagnosis of Gastro-Intestinal Perforation by the Rectal Insufflation of Hydrogen Gas. Annals of Surgery, 1888. 8(3): p. 190-204.

Zhang, X., et al., Subcutaneous injection of hydrogen gas is a novel effective treatment for type 2 diabetes. J Diabetes Investig, 2018. 9(1): p. 83-90.

Korovljev, D., et al., Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women. Ir J Med Sci, 2017.

Hou, C., et al., Coral calcium hydride prevents hepatic steatosis in high fat diet-induced obese rats: A potent mitochondrial nutrient and phase II enzyme inducer. Biochem Pharmacol, 2016. 103: p. 85-97.

Zong, C., et al., Cigarette smoke exposure impairs reverse cholesterol transport which can be minimized by treatment of hydrogen-saturated saline. Lipids Health Dis, 2015. 14: p. 159.

Song, G., et al., Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome. Journal of Lipid Research, 2013. 54(7): p. 1884-93.

Jiang, H., et al., Hydrogen-rich medium suppresses the generation of reactive oxygen species, elevates the Bcl-2/Bax ratio and inhibits advanced glycation end product-induced apoptosis. Int J Mol Med, 2013. 31(6): p. 1381-7.

Iio, A., et al., Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells. Medical Gas Research, 2013. 3(1): p. 6.

Ignacio, R.M., et al., Anti-obesity effect of alkaline reduced water in high fat-fed obese mice. Biol Pharm Bull, 2013. 36(7): p. 1052-9.

He, B., et al., Protection of oral hydrogen water as an antioxidant on pulmonary hypertension. Mol Biol Rep, 2013. 40(9): p. 5513-21.

Fan, M., et al., Protective effects of hydrogen-rich saline against erectile dysfunction in a streptozotocin induced diabetic rat model. Journal of Urology, 2013. 190(1): p. 350-6.

Chen, Y., et al., Hydrogen-rich saline attenuates vascular smooth muscle cell proliferation and neointimal hyperplasia by inhibiting reactive oxygen species production and inactivating the Ras-ERK1/2-MEK1/2 and Akt pathways. International Journal of Molecular Medicine, 2013. 31(3): p. 597-606.

Baek, D.-H., Antibacterial Activity of Hydrogen-rich Water Against Oral Bacteria.

Amitani, H., et al., Hydrogen Improves Glycemic Control in Type1 Diabetic Animal Model by Promoting Glucose Uptake into Skeletal Muscle. PLoS One, 2013. 8(1).

Zong, C., et al., Administration of hydrogen-saturated saline decreases plasma low-density lipoprotein cholesterol levels and improves high-density lipoprotein function in high-fat diet-fed hamsters. Metabolism, 2012. 61(6): p. 794-800.

Zheng, H. and Y.S. Yu, Chronic hydrogen-rich saline treatment attenuates vascular dysfunction in spontaneous hypertensive rats. Biochemical Pharmacology, 2012. 83(9): p. 1269-77.

Yu, Y.S. and H. Zheng, Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats. Mol Cell Biochem, 2012. 365(1-2): p. 233-42.

Wang, Q.J., et al., Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress. Chin Med J (Engl), 2012. 125(9): p. 1633-7.

Tanabe, H., et al., Suppressive Effect of High Hydrogen Generating High Amylose Cornstarch on Subacute Hepatic Ischemia-reperfusion Injury in Rats. Biosci Microbiota Food Health, 2012. 31(4): p. 103-8.

Song, G., et al., Hydrogen decreases athero-susceptibility in apolipoprotein B-containing lipoproteins and aorta of apolipoprotein E knockout mice. Atherosclerosis, 2012. 221(1): p. 55-65.

Nishioka, S., et al., Effect of hydrogen gas inhalation on lipid metabolism and left ventricular remodeling induced by intermittent hypoxia in mice. European Heart Journal, 2012. 33: p. 794-794.

Kawai, D., et al., Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice. Hepatology, 2012. 56(3): p. 912-21.

Fan, M., et al., Protective Effects of Hydrogen-Rich Saline Against Erectile Dysfunction in a Streptozotocin Induced Diabetic Rat Model. J Urol, 2012.

Ekuni, D., et al., Hydrogen-rich water prevents lipid deposition in the descending aorta in a rat periodontitis model. Arch Oral Biol, 2012. 57(12): p. 1615-22.

Yu, P., et al., Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage. Biochemical and Biophysical Research Communications, 2011. 409(2): p. 350-5.

Yang, X., et al., Protective effects of hydrogen-rich saline in preeclampsia rat model. Placenta, 2011. 32(9): p. 681-6.

Wang, Y., et al., Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model. Respir Res, 2011. 12: p. 26.

Song, G., et al., H2 inhibits TNF-alpha-induced lectin-like oxidized LDL receptor-1 expression by inhibiting nuclear factor kappaB activation in endothelial cells. Biotechnology Letters, 2011. 33(9): p. 1715-22.

Shirahata, S., et al., Anti-diabetes effect of water containing hydrogen molecule and Pt nanoparticles. BMC Proc, 2011. 5 Suppl 8: p. P18.

Nakai, Y., et al., Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated drinking water. Bioscience, Biotechnology, and Biochemistry, 2011. 75(4): p. 774-6.

Li, Y., et al., Suppressive effects of electrolyzed reduced water on alloxan-induced apoptosis and type 1 diabetes mellitus. Cytotechnology, 2011. 63(2): p. 119-31.

Kamimura, N., et al., Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice. Obesity, 2011.

Hashimoto, M., et al., Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat – a metabolic syndrome rat model. Medical Gas Research, 2011. 1(1): p. 26.

Nakao, A., et al., Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects with Potential Metabolic Syndrome-An Open Label Pilot Study. Journal of Clinical Biochemistry and Nutrition, 2010. 46(2): p. 140-149.

Chen, C.H., et al., Hydrogen Gas Reduced Acute Hyperglycemia-Enhanced Hemorrhagic Transformation in a Focal Ischemia Rat Model. Neuroscience, 2010. 169(1): p. 402-414.

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Chao, Y.C. and M.T. Chiang, Effect of alkaline reduced water on erythrocyte oxidative status and plasma lipids of spontaneously hypertensive rats. Taiwanese Journal of Agricultural Chemistry and Food Science, 2009. 47(2): p. 71-72.

Ohsawa, I., et al., Consumption of hydrogen water prevents atherosclerosis in apoliporotein E knockout mice. Biochem Biophys Res Commun, 2008. 377(4): p. 1195-8.

Kajiyama, S., et al., Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutrition Research, 2008. 28: p. 137–143.

Kim, M.J., et al., Preservative effect of electrolyzed reduced water on pancreatic beta-cell mass in diabetic db/db mice. Biol Pharm Bull, 2007. 30(2): p. 234-6.

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