A growing body of research ~ see below ~ is exploring the potential benefits of molecular hydrogen in various fields, including exercise and athletics, oxidative stress-related conditions, and disease management. Studies have shown that acute supplementation with molecular hydrogen can benefit submaximal exercise indices, alleviate oxygen toxicity by reducing hydroxyl radical levels in cells, and reduce acute hyperglycemia-enhanced hemorrhagic transformation in ischemia models. Additionally, molecular hydrogen has been investigated for its effects on cellular senescence, antioxidant defense in gastrointestinal diseases, and treatment of conditions such as retinal injury, psoriasis, and multiple sclerosis. Moreover, research suggests that molecular hydrogen may have a therapeutic role in COVID-19 treatment by modulating cellular pathways involved in senescence, inflammation, and immune response. These studies highlight the diverse potential applications of molecular hydrogen in promoting health and well-being across different physiological systems and disease states.
Miscellaneous
COVID-19: Molecular Hydrogen ~ A Promising Adjunctive Strategy for the Treatment of the COVID-19
Zhang, W., et al., Hydrogen alleviates cellular senescence via regulation of ROS/p53/p21 pathway in bone marrow-derived mesenchymal stem cells in vivo. Biomedicine & Pharmacotherapy, 2018. 106: p. 1126-1134.
Nishiwaki, H., et al., Molecular hydrogen upregulates heat shock response and collagen biosynthesis, and downregulates cell cycles – Meta-analyses of gene expression profiles. Free Radic Res, 2018: p. 1-311.
de Maistre, S., et al., Stimulating fermentation by the prolonged acceleration of gut transit protects against decompression sickness. Sci Rep, 2018. 8(1): p. 10128.
Zhao, J., et al., Therapeutic Effect of Hydrogen Injected Subcutaneously on Onion Poisoned Dogs. J Vet Res, 2017. 61(4): p. 527-533.
Yu, J., et al., Hydrogen gas alleviates oxygen toxicity by reducing hydroxyl radical levels in PC12 cells. PLoS One, 2017. 12(3): p. e0173645.
Sun, Q., et al., Hydrogen alleviates hyperoxic acute lung injury related endoplasmic reticulum stress in rats through upregulation of SIRT1. Free Radic Res, 2017. 51(6): p. 622-632.
Sobue, S., et al., Molecular hydrogen modulates gene expression via histone modification and induces the mitochondrial unfolded protein response. Biochem Biophys Res Commun, 2017. 493(1): p. 318-324.
Hu, Z., et al., Impact of molecular hydrogen treatments on the innate immune activity and survival of zebrafish (Danio rerio) challenged with Aeromonas hydrophila. Fish Shellfish Immunol, 2017. 67: p. 554-560.
Hamasaki, T., et al., Electrochemically reduced water exerts superior reactive oxygen species scavenging activity in HT1080 cells than the equivalent level of hydrogen-dissolved water. PLoS One, 2017. 12(2): p. e0171192.
Yang, T., et al., Hydrogen-Rich Medium Ameliorates Lipopolysaccharide-Induced Barrier Dysfunction Via Rhoa-Mdia1 Signaling in Caco-2 Cells. Shock, 2016. 45(2): p. 228-37.
Settineri, R., et al., Effects of Hydrogenized Water on Intracellular Biomarkers for Antioxidants, Glucose Uptake, Insulin Signaling and SIRT 1 and Telomerase Activity. American Journal of Food and Nutrition, 2016. 4(6): p. 161-168.
Ren, J.D., et al., Molecular hydrogen inhibits lipopolysaccharide-triggered NLRP3 inflammasome activation in macrophages by targeting the mitochondrial reactive oxygen species. Biochim Biophys Acta, 2016. 1863(1): p. 50-5.
Pshenichnyuk, S.A., et al., Hypothesis for the Mechanism of Ascorbic Acid Activity in Living Cells Related to Its Electron-Accepting Properties. The Journal of Physical Chemistry A, 2016. 120(17): p. 2667-2676.
Lin, Y., et al., Molecular hydrogen suppresses activated Wnt/beta-catenin signaling. Sci Rep, 2016. 6: p. 31986.
Li, J., et al., The Effects of Molecular Hydrogen and Suberoylanilide Hydroxamic Acid on Paraquat-Induced Production of Reactive Oxygen Species and TNF-alpha in Macrophages. Inflammation, 2016. 39(6): p. 1990-1996.
Kamimura, N., et al., Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1 [alpha] to enhance fatty acid metabolism. NPJ Aging and Mechanisms of Disease, 2016. 2: p. 16008.
Iuchi, K., et al., Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators. Sci Rep, 2016. 6: p. 18971.
Kato, S., D. Matsuoka, and N. Miwa, Antioxidant activities of nano-bubble hydrogen-dissolved water assessed by ESR and 2, 2′-bipyridyl methods. Materials Science and Engineering:, 2015. C 53: p. 7-10.
Hyspler, R., et al., The Evaluation and Quantitation of Dihydrogen Metabolism Using Deuterium Isotope in Rats. PLoS One, 2015. 10(6): p. e0130687.
Penders, J., R. Kissner, and W.H. Koppenol, ONOOH does not react with H2. Free Radic Biol Med, 2014.
Qian, L., et al., Administration of hydrogen-rich saline protects mice from lethal acute graft-versus-host disease (aGVHD). Transplantation, 2013. 95(5): p. 658-62.
Park, S.K., et al., Electrolyzed-reduced water confers increased resistance to environmental stresses. Molecular & Cellular Toxicology, 2012. 8(3): p. 241-247.
Yan, H., et al., Mechanism of the lifespan extension of Caenorhabditis elegans by electrolyzed reduced water–participation of Pt nanoparticles. Bioscience, Biotechnology, and Biochemistry, 2011. 75(7): p. 1295-9.
Yan, H.X., et al., Extension of the Lifespan of Caenorhabditis elegans by the Use of Electrolyzed Reduced Water. Bioscience Biotechnology and Biochemistry, 2010. 74(10): p. 2011-2015.
Yan, H., et al., electrolyzed reduced water prolongs caenorhabditis elegans lifespan, in Animal Cell Technology: Basic & Applied Aspects. 2010, Springer Netherlands. p. 289-293.
Hiraoka, A., et al., In Vitro Physicochemical Properties of Neutral Aqueous Solution Systems (Water Products as Drinks) Containing Hydrogen Gas, 2-Carboxyethyl Germanium Sesquioxide, and Platinum Nanocolloid as Additives. Journal of Health Science, 2010. 56(2): p. 167-174.
Ohsawa, I., et al., Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med, 2007. 13(6): p. 688-694.
Zhang, Y.G., et al., Hydrogen-rich saline promotes motor functional recovery following peripheral nerve autografting in rats. Exp Ther Med, 2015. 10(2): p. 727-732.
Chen, Y., et al., H Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain. Inflammation, 2015.
Kawaguchi, M., et al., Molecular hydrogen attenuates neuropathic pain in mice. PLoS One, 2014. 9(6): p. e100352.
Ge, Y., et al., Intrathecal Infusion of Hydrogen-Rich Normal Saline Attenuates Neuropathic Pain via Inhibition of Activation of Spinal Astrocytes and Microglia in Rats. PLoS One, 2014. 9(5): p. e97436.
Zhao, S., et al., Therapeutic effects of hydrogen-rich solution on aplastic anemia in vivo. Cell Physiol Biochem, 2013. 32(3): p. 549-60.
Wang, W.N., et al., [Regulative effects of hydrogen-rich medium on monocytic adhesion and vascular endothelial permeability]. Zhonghua Yi Xue Za Zhi, 2013. 93(43): p. 3467-9.
Li, F.Y., et al., Consumption of hydrogen-rich water protects against ferric nitrilotriacetate-induced nephrotoxicity and early tumor promotional events in rats. Food Chem Toxicol, 2013. 61: p. 248-54.
Morita, C., T. Nishida, and K. Ito, Biological toxicity of acid electrolyzed functional water: effect of oral administration on mouse digestive tract and changes in body weight. Arch Oral Biol, 2011. 56(4): p. 359-66.
Takenouchi, T. and S. Hayase, Qualitative Analysis for Trace Amounts of Organocompounds Derived from Constitutional Materials of Electrolytic Compartments During Generation of an Acidic Electrolyzed Water. Bunseki Kagaku, 2010. 59(9): p. 817-821.
Kikuchi, K., et al., Concentration determination of oxygen nanobubbles in electrolyzed water. Journal of Colloid and Interface Science, 2009. 329(2): p. 306-309.
, Permeability and dissolvability of cathodic electrolyzed water for electrophoretic gel and green tea components. Journal of the Korea Academia-Industrial cooperation Society, 2005. 6(1): p. 87-93.
Yahagi, N., et al., Effect of electrolyzed water on wound healing. Artificial Organs, 2000. 24(12): p. 984-987.
Koseki, S. and K. Itoh, Fundamental properties of electrolyzed water. Journal of the Japanese Society for Food Science and Technology-Nippon Shokuhin Kagaku Kogaku Kaishi, 2000. 47(5): p. 390-393.
Hiraoka, A., et al., Studies on the properties and real existence of aqueous solution systems that are assumed to have antioxidant activities by the action of “active hydrogen”‘. Journal of Health Science, 2004. 50(5): p. 456-465.
Hanaoka, K., et al., The mechanism of the enhanced antioxidant effects against superoxide anion radicals of reduced water produced by electrolysis. Biophysical Chemistry, 2004. 107(1): p. 71-82.
Hanaoka, K., Antioxidant effects of reduced water produced by electrolysis of sodium chloride solutions. Journal of Applied Electrochemistry, 2001. 31(12): p. 1307-1313.
