The research papers below explore the anti-inflammatory properties of molecular hydrogen in liver-related conditions. Studies highlight its protective effects in parasite-induced liver inflammation, Concanavalin A-induced hepatitis, and liver fibrogenesis in mice. Additionally, research demonstrates the benefits of hydrogen-rich saline in mitigating liver injury in various models. Overall, the findings suggest that molecular hydrogen shows promise as a therapeutic agent for liver health.
353.Gharib, B., et al., Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation. C R Acad Sci III, 2001. 324(8): p. 719-724.
354.Itoh, T., et al., Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells. Biochem Biophys Res Commun, 2009. 389(4): p. 651-6.
355.Kajiya, M., et al., Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis. Biochem Biophys Res Commun, 2009. 386(2): p. 316-21.
356.Koyama, Y., et al., Effects of Oral Intake of Hydrogen Water on Liver Fibrogenesis in Mice. Hepatol Res, 2013.
357.Koyama, Y., et al., Effects of oral intake of hydrogen water on liver fibrogenesis in mice. Hepatol Res, 2014. 44(6): p. 663-677.
358.Lee, P.C., et al., Concomitant inhibition of oxidative stress and angiogenesis by chronic hydrogen-rich saline and N-acetylcysteine treatments improves systemic, splanchnic and hepatic hemodynamics of cirrhotic rats.Hepatol Res, 2014.
359.Liu, G.D., et al., Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells. Int J Ophthalmol, 2013. 6(3): p. 280-5.
360.Liu, Q., et al., Hydrogen-rich saline protects against liver injury in rats with obstructive jaundice. Liver International, 2010. 30(7): p. 958-968.
361.Liu, Y., et al., Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release. BMC Gastroenterol, 2014. 14: p. 12.
362.Matsuno, N., et al., Beneficial effects of hydrogen gas on porcine liver reperfusion injury with use of total vascular exclusion and active venous bypass. Transplant Proc, 2014. 46(4): p. 1104-6.
363.Nishimura, N., et al., Pectin and high-amylose maize starch increase caecal hydrogen production and relieve hepatic ischaemia-reperfusion injury in rats. Br J Nutr, 2012. 107(4): p. 485-92.
364.Park, S.K., et al., Electrolyzed-reduced water inhibits acute ethanol-induced hangovers in Sprague-Dawley rats. Biomed Res, 2009. 30(5): p. 263-9.
365.Shen, M.H., et al., Hydrogen as a novel and effective treatment of acute carbon monoxide poisoning. Medical Hypotheses, 2010. 75(2): p. 235-237.
366.Sun, H., et al., The protective role of hydrogen-rich saline in experimental liver injury in mice. Journal of Hepatology, 2011. 54(3): p. 471-80.
367.Tan, Y.C., et al., Hydrogen-rich saline attenuates postoperative liver failure after major hepatectomy in rats. Clin Res Hepatol Gastroenterol, 2014. 38(3): p. 337-45.
568.Tange, Y., S. Takesawa, and S. Yoshitake, Dialysate with high dissolved hydrogen facilitates dissociation of indoxyl sulfate from albumin. Nephrourol Mon, 2015. 7(2): p. e26847.
369.Tsai, C.F., et al., Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice. Food Chem Toxicol, 2009. 47(8): p. 2031-6.
370.Wang, W., et al., Effects of hydrogen-rich saline on rats with acute carbon monoxide poisoning. Journal of Emergency Medicine, 2013. 44(1): p. 107-15.
371.Xiang, L., et al., Inhalation of hydrogen gas reduces liver injury during major hepatotectomy in swine. World Journal of Gastroenterology, 2012. 18(37): p. 5197-5204.
372.Xu, X.F. and J. Zhang, Saturated hydrogen saline attenuates endotoxin-induced acute liver dysfunction in rats. Physiol Res, 2013. 62(4): p. 395-403.
373.Zhang, C.B., et al., Hydrogen gas inhalation protects against liver ischemia/reperfusion injury by activating the NF-κB signaling pathway. Experimental and Therapeutic Medicine, 2015. 9(6): p. 2114-2120.
374.Zhang, J.Y., et al., Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice. World J Gastroenterol, 2015. 21(14): p. 4195-209.
Li, H., et al., Hydrogen-rich saline protects against small-scale liver ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress. Life Sci, 2018. 194: p. 7-14.
Ishikawa, T., et al., Post-reperfusion hydrogen gas treatment ameliorates ischemia reperfusion injury in rat livers from donors after cardiac death: a preliminary study. Surg Today, 2018.
Chen, M., et al., Hydrogen protects against liver injury during CO2 pneumoperitoneum in rats. Oncotarget, 2018. 9(2): p. 2631-2645.
Zhai, X., et al., Hydrogen-rich saline improves nonalcoholic fatty liver disease by alleviating oxidative stress and activating hepatic PPARalpha and PPARgamma. Mol Med Rep, 2017. 15(3): p. 1305-1312.
Wang, D., et al., The protective role of hydrogen-rich saline against liver injury caused by acetaminophen in mice. Int J Clin Exp Med, 2017. 10(8): p. 11646-11654.
Uto, K., et al., Hydrogen Rich Solution Attenuates Cold Ischemia-Reperfusion Injury in Rat Liver Transplantation. Transplantation, 2017. 101(5S-3): p. S18.
Lin, C.P., et al., Anti-oxidant and anti-inflammatory effects of hydrogen-rich water alleviate ethanol-induced fatty liver in mice. World J Gastroenterol, 2017. 23(27): p. 4920-4934.
Li, H., et al., Inhalation of high concentrations of hydrogen ameliorates liver ischemia/reperfusion injury through A2A receptor mediated PI3K-Akt pathway. Biochem Pharmacol, 2017. 130: p. 83-92.
Iketani, M., et al., Preadministration of Hydrogen-Rich Water Protects Against Lipopolysaccharide-Induced Sepsis and Attenuates Liver Injury. Shock, 2017. 48(1): p. 85-93.
Golshahi, H., et al., Protective effect of intraportal infusion of hypothermic hydrogen-rich saline solution on hepatic warm ischemia/reperfusion injury in rat model. Brazilian Journal of Veterinary Pathology, 2017. 10(1): p. 10-21.
Shimada, S., et al., Hydrogen Gas Ameliorates Hepatic Reperfusion Injury After Prolonged Cold Preservation in Isolated Perfused Rat Liver. Artif Organs, 2016. 40(12): p. 1128-1136.
Shi, Q., et al., Hydrogen-Rich Saline Attenuates Acute Hepatic Injury in Acute Necrotizing Pancreatitis by Inhibiting Inflammation and Apoptosis, Involving JNK and p38 Mitogen-Activated Protein Kinase-dependent Reactive Oxygen Species. Pancreas, 2016. 45(10): p. 1424-1431.
Liu, Q., et al., Hydrogen-rich saline protects against mitochondrial dysfunction and apoptosis in mice with obstructive jaundice. Mol Med Rep, 2016. 13(4): p. 3588-96.
Zhang, J.Y., et al., Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice. World J Gastroenterol, 2015. 21(14): p. 4195-209.
Zhang, C.B., et al., Hydrogen gas inhalation protects against liver ischemia/reperfusion injury by activating the NF-κB signaling pathway. Experimental and Therapeutic Medicine, 2015. 9(6): p. 2114-2120.
Yu, J., et al., Molecular hydrogen attenuates hypoxia/reoxygenation injury of intrahepatic cholangiocytes by activating Nrf2 expression. Toxicol Lett, 2015. 238(3): p. 11-19.
Sobue, S., et al., Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents. Mol Cell Biochem, 2015. 403(1-2): p. 231-41.
Lee, P.C., et al., Concomitant inhibition of oxidative stress and angiogenesis by chronic hydrogen-rich saline and N-acetylcysteine treatments improves systemic, splanchnic and hepatic hemodynamics of cirrhotic rats. Hepatol Res, 2015. 45(5): p. 578-88.
Tan, Y.C., et al., Hydrogen-rich saline attenuates postoperative liver failure after major hepatectomy in rats. Clin Res Hepatol Gastroenterol, 2014. 38(3): p. 337-45.
Matsuno, N., et al., Beneficial effects of hydrogen gas on porcine liver reperfusion injury with use of total vascular exclusion and active venous bypass. Transplant Proc, 2014. 46(4): p. 1104-6.
Liu, Y., et al., Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release. BMC Gastroenterol, 2014. 14: p. 12.
Koyama, Y., et al., Effects of oral intake of hydrogen water on liver fibrogenesis in mice. Hepatol Res, 2014. 44(6): p. 663-677.
Xu, X.F. and J. Zhang, Saturated hydrogen saline attenuates endotoxin-induced acute liver dysfunction in rats. Physiol Res, 2013. 62(4): p. 395-403.
Xia, C., et al., Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B. Clin Transl Sci, 2013. 6(5): p. 372-5.
Wang, W., et al., Effects of hydrogen-rich saline on rats with acute carbon monoxide poisoning. Journal of Emergency Medicine, 2013. 44(1): p. 107-15.
Liu, G.D., et al., Molecular hydrogen regulates the expression of miR-9, miR-21 and miR-199 in LPS-activated retinal microglia cells. Int J Ophthalmol, 2013. 6(3): p. 280-5.
Xiang, L., et al., Inhalation of hydrogen gas reduces liver injury during major hepatotectomy in swine. World Journal of Gastroenterology, 2012. 18(37): p. 5197-5204.
Nishimura, N., et al., Pectin and high-amylose maize starch increase caecal hydrogen production and relieve hepatic ischaemia-reperfusion injury in rats. Br J Nutr, 2012. 107(4): p. 485-92.
Sun, H., et al., The protective role of hydrogen-rich saline in experimental liver injury in mice. Journal of Hepatology, 2011. 54(3): p. 471-80.
Shen, M.H., et al., Hydrogen as a novel and effective treatment of acute carbon monoxide poisoning. Medical Hypotheses, 2010. 75(2): p. 235-237.
Liu, Q., et al., Hydrogen-rich saline protects against liver injury in rats with obstructive jaundice. Liver International, 2010. 30(7): p. 958-968.
Tsai, C.F., et al., Hepatoprotective effect of electrolyzed reduced water against carbon tetrachloride-induced liver damage in mice. Food Chem Toxicol, 2009. 47(8): p. 2031-6.
Park, S.K., et al., Electrolyzed-reduced water inhibits acute ethanol-induced hangovers in Sprague-Dawley rats. Biomed Res, 2009. 30(5): p. 263-9.
Kajiya, M., et al., Hydrogen from intestinal bacteria is protective for Concanavalin A-induced hepatitis. Biochem Biophys Res Commun, 2009. 386(2): p. 316-21.
Itoh, T., et al., Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells. Biochem Biophys Res Commun, 2009. 389(4): p. 651-6.
Gharib, B., et al., Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation. C R Acad Sci III, 2001. 324(8): p. 719-724.
