The research studies below on hydrogen therapy presented a diverse range of potential benefits across various medical conditions and models of ischemia-reperfusion injury. Studies by Cai et al. (2008, 2009) demonstrated the neuroprotective effects of hydrogen therapy in neonatal hypoxia-ischemia rat models. Chen et al. (2011) investigated the effects of hydrogen-rich saline on intestinal contractile and structural changes induced by ischemia-reperfusion in rats. Other studies, such as those by Fukuda et al. (2007), Ge et al. (2012), and Han et al. (2015), explored the protective effects of inhaled hydrogen gas on hepatic, cognitive, and brain injuries caused by ischemia-reperfusion. Additionally, research by Hayashida et al. (2008), Huang et al. (2011), and Ji et al. (2011) highlighted the cardioprotective and neuroprotective properties of hydrogen-rich saline in models of heart, lung, and brain ischemia-reperfusion injuries. These studies collectively suggest the potential therapeutic value of hydrogen-rich solutions in mitigating oxidative stress, reducing inflammation, and improving outcomes in various ischemic conditions.
298.Cai, J., et al., Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci Lett, 2008. 441(2): p. 167-172.
299.Cai, J.M., et al., Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model. Brain Res, 2009. 1256: p. 129-137.
300.Chen, H., et al., The effects of hydrogen-rich saline on the contractile and structural changes of intestine induced by ischemia-reperfusion in rats. Journal of Surgical Research, 2011. 167(2): p. 316-22.
301.Fukuda, K., et al., Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun, 2007. 361(3): p. 670-674.
302.Ge, P., et al., Inhalation of hydrogen gas attenuates cognitive impairment in transient cerebral ischemia via inhibition of oxidative stress. Neurological Research, 2012. 34(2): p. 187-94.
303.Han, L., et al., Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering proteins. Brain Res, 2015.
304.Hayashida, K., et al., Inhalation of hydrogen gas protects the heart from ischemic reperfusion injury. Journal of the American College of Cardiology, 2008. 51(10): p. A375-A375.
305.Hayashida, K., et al., Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Journal of Cardiac Failure, 2008. 14(7): p. S168-S168.
306.Huang, Y., et al., Beneficial effects of hydrogen gas against spinal cord ischemia-reperfusion injury in rabbits. Brain Research, 2011. 1378: p. 125-136.
307.Huang, T., et al., Hydrogen-rich saline attenuates ischemia-reperfusion injury in skeletal muscle. J Surg Res, 2015. 194(2): p. 471-80.
308.Ji, Q., et al., The effect of hydrogen-rich saline on the brain of rats with transient ischemia. Journal of Surgical Research, 2011. 168(1): p. e95-e101.
309.Jiang, D., et al., Protective effects of hydrogen rich saline solution on experimental testicular ischemia-reperfusion injury in rats. J Urol, 2012. 187(6): p. 2249-53.
310.Kawamura, T., et al., Inhaled Hydrogen Gas Therapy for Prevention of Lung Transplant-Induced Ischemia/Reperfusion Injury in Rats. Transplantation, 2010. 90(12): p. 1344-1351.
311.Kuroki, C., et al., Neuroprotective Effects of Hydrogen Gas on Brain in Ischemia-Reperfusion Model: A P-31-Nmr Study. Journal of Physiological Sciences, 2009. 59: p. 371-371.
312.Kuroki, C., et al., Neuroprotective effects of hydrogen gas on brain in hypoxic stress model and ischemia-reperfusion model: A P-31 NMR study. Neuroscience Research, 2008. 61: p. S274-S274.
313.Lee, J.W., et al., Inhaled hydrogen gas therapy for prevention of testicular ischemia/reperfusion injury in rats. Journal of Pediatric Surgery, 2012. 47(4): p. 736-742.
314.Li, H., et al., Hydrogen-rich saline attenuates lung ischemia-reperfusion injury in rabbits. Journal of Surgical Research, 2012. 174(1): p. e11-6.
315.Li, J., et al., Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via reducing oxidative stress and inflammatory cytokines. Brain Research, 2012. 1486: p. 103-11.
316.Liu, Y., et al., Hydrogen saline offers neuroprotection by reducing oxidative stress in a focal cerebral ischemia-reperfusion rat model. Medical Gas Research, 2011. 1(1): p. 15.
317.Liu, Y.Q., et al., Hydrogen-rich saline attenuates skin ischemia/reperfusion induced apoptosis via regulating Bax/Bcl-2 ratio and ASK-1/JNK pathway. Reconstructive & Aesthetic Surgery, 2015.
318.Liu, R., et al., Lung inflation with hydrogen during the cold ischemia phase decreases lung graft injury in rats. Exp Biol Med (Maywood), 2015.
319.Luo, Z.L., et al., Hydrogen-Rich Saline Protects against Ischemia/Reperfusion Injury in Grafts after Pancreas Transplantations by Reducing Oxidative Stress in Rats. Mediators Inflamm, 2015. 2015: p. 281985.
320.Mao, Y.F., et al., Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. Biochem Biophys Res Commun, 2009. 381(4): p. 602-5.
321.Matchett, G.A., et al., Hydrogen gas is ineffective in moderate and severe neonatal hypoxia-ischemia rat models. Brain Research, 2009. 1259: p. 90-7.
322.Nagatani, K., et al., Effect of Hydrogen Gas on the Survival Rate of Mice Following Global Cerebral Ischemia. Shock 37(6):645-652, 2012 Reply. Shock, 2012. 38(4): p. 444-445.
323.Nagatani, K., et al., Effect of Hydrogen Gas on the Survival Rate of Mice Following Global Cerebral Ischemia. Shock, 2012. 37(6): p. 645-652.
324.Nakao, A., et al., Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2010. 29(5): p. 544-53.
325.Noda, K., et al., A novel method of preserving cardiac grafts using a hydrogen-rich water bath. Journal of Heart and Lung Transplantation, 2013. 32(2): p. 241-50.
326.Shingu, C., et al., Hydrogen-rich saline solution attenuates renal ischemia-reperfusion injury. Journal of Anesthesia, 2010. 24(4): p. 569-574.
327.Sun, Q., et al., Hydrogen-Rich Saline Protects Myocardium Against Ischemia/Reperfusion Injury in Rats. Experimental Biology and Medicine, 2009. 234(10): p. 1212-1219.
328.Tan, M., et al., Hydrogen as additive of HTK solution fortifies myocardial preservation in grafts with prolonged cold ischemia. International Journal of Cardiology, 2013. 167(2): p. 383-90.
329.Wang, F., et al., Hydrogen-Rich Saline Protects Against Renal Ischemia/Reperfusion Injury in Rats. Journal of Surgical Research, 2011. 167(2): p. e339-44.
330.Yonamine, R., et al., Coadministration of hydrogen gas as part of the carrier gas mixture suppresses neuronal apoptosis and subsequent behavioral deficits caused by neonatal exposure to sevoflurane in mice.Anesthesiology, 2013. 118(1): p. 105-13.
331.Zhang, J., et al., Effect of hydrogen gas on the survival rate of mice following global cerebral ischemia (Shock 37(6), 645-652, 2012). Shock, 2012. 38(4): p. 444; author reply 444-5.
332.Zhang, Y., et al., Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion. International Journal of Cardiology, 2011. 148(1): p. 91-5.
333.Zhao, L., et al., Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap. J Zhejiang Univ Sci B, 2013. 14(5): p. 382-91.
334.Zheng, X., et al., Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats. Free Radic Res, 2009. 43(5): p. 478-84.
335.Zhou, H., et al., Hydrogen inhalation decreases lung graft injury in brain-dead donor rats. Journal of Heart and Lung Transplantation, 2013. 32(2): p. 251-8.
336.Zhou, L., et al., Beneficial effects of hydrogen-rich saline against spinal cord ischemia-reperfusion injury in rabbits. Brain Research, 2013. 1517: p. 150-60.
337.Zhu, W.J., et al., Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats. Nephrology, Dialysis, Transplantation, 2011. 26(7): p. 2112-8.
Liu, H., et al., Hydrogen-rich saline reduces cell death through inhibition of DNA oxidative stress and overactivation of poly (ADP-ribose) polymerase-1 in retinal ischemia-reperfusion Hinjury. Mol Med Rep, 2015. 12(2): p. 2495-502.
Huang, T., et al., Hydrogen-rich saline attenuates ischemia-reperfusion injury in skeletal muscle. J Surg Res, 2015. 194(2): p. 471-80.
Zhou, L., et al., Beneficial effects of hydrogen-rich saline against spinal cord ischemia-reperfusion injury in rabbits. Brain Research, 2013. 1517: p. 150-60.
Zhou, H., et al., Hydrogen inhalation decreases lung graft injury in brain-dead donor rats. Journal of Heart and Lung Transplantation, 2013. 32(2): p. 251-8.
Zhao, L., et al., Protective effect of hydrogen-rich saline on ischemia/reperfusion injury in rat skin flap. J Zhejiang Univ Sci B, 2013. 14(5): p. 382-91.
Yonamine, R., et al., Coadministration of hydrogen gas as part of the carrier gas mixture suppresses neuronal apoptosis and subsequent behavioral deficits caused by neonatal exposure to sevoflurane in mice. Anesthesiology, 2013. 118(1): p. 105-13.
Tan, M., et al., Hydrogen as additive of HTK solution fortifies myocardial preservation in grafts with prolonged cold ischemia. International Journal of Cardiology, 2013. 167(2): p. 383-90.
Noda, K., et al., A novel method of preserving cardiac grafts using a hydrogen-rich water bath. Journal of Heart and Lung Transplantation, 2013. 32(2): p. 241-50.
Zhang, J., et al., Effect of hydrogen gas on the survival rate of mice following global cerebral ischemia (Shock 37(6), 645-652, 2012). Shock, 2012. 38(4): p. 444; author reply 444-5.
Nagatani, K., et al., Effect of Hydrogen Gas on the Survival Rate of Mice Following Global Cerebral Ischemia. Shock, 2012. 37(6): p. 645-652.
Li, J., et al., Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via reducing oxidative stress and inflammatory cytokines. Brain Research, 2012. 1486: p. 103-11.
Li, H., et al., Hydrogen-rich saline attenuates lung ischemia-reperfusion injury in rabbits. Journal of Surgical Research, 2012. 174(1): p. e11-6.
Lee, J.W., et al., Inhaled hydrogen gas therapy for prevention of testicular ischemia/reperfusion injury in rats. Journal of Pediatric Surgery, 2012. 47(4): p. 736-742.
Jiang, D., et al., Protective effects of hydrogen rich saline solution on experimental testicular ischemia-reperfusion injury in rats. J Urol, 2012. 187(6): p. 2249-53.
Ge, P., et al., Inhalation of hydrogen gas attenuates cognitive impairment in transient cerebral ischemia via inhibition of oxidative stress. Neurological Research, 2012. 34(2): p. 187-94.
Zhu, W.J., et al., Intake of water with high levels of dissolved hydrogen (H2) suppresses ischemia-induced cardio-renal injury in Dahl salt-sensitive rats. Nephrology, Dialysis, Transplantation, 2011. 26(7): p. 2112-8.
Zhang, Y., et al., Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion. International Journal of Cardiology, 2011. 148(1): p. 91-5.
Wang, F., et al., Hydrogen-Rich Saline Protects Against Renal Ischemia/Reperfusion Injury in Rats. Journal of Surgical Research, 2011. 167(2): p. e339-44.
Liu, Y., et al., Hydrogen saline offers neuroprotection by reducing oxidative stress in a focal cerebral ischemia-reperfusion rat model. Medical Gas Research, 2011. 1(1): p. 15.
Ji, Q., et al., The effect of hydrogen-rich saline on the brain of rats with transient ischemia. Journal of Surgical Research, 2011. 168(1): p. e95-e101.
Huang, Y., et al., Beneficial effects of hydrogen gas against spinal cord ischemia-reperfusion injury in rabbits. Brain Research, 2011. 1378: p. 125-136.
Chen, H., et al., The effects of hydrogen-rich saline on the contractile and structural changes of intestine induced by ischemia-reperfusion in rats. Journal of Surgical Research, 2011. 167(2): p. 316-22.
Shingu, C., et al., Hydrogen-rich saline solution attenuates renal ischemia-reperfusion injury. Journal of Anesthesia, 2010. 24(4): p. 569-574.
Nakao, A., et al., Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both. The Journal of heart and lung transplantation: the official publication of the International Society for Heart Transplantation, 2010. 29(5): p. 544-53.
Kawamura, T., et al., Inhaled Hydrogen Gas Therapy for Prevention of Lung Transplant-Induced Ischemia/Reperfusion Injury in Rats. Transplantation, 2010. 90(12): p. 1344-1351.
Zheng, X., et al., Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats. Free Radic Res, 2009. 43(5): p. 478-84.
Sun, Q., et al., Hydrogen-Rich Saline Protects Myocardium against Ischemia/Reperfusion Injury in Rats. Experimental Biology and Medicine, 2009. 234(10): p. 1212-1219.
Matchett, G.A., et al., Hydrogen gas is ineffective in moderate and severe neonatal hypoxia-ischemia rat models. Brain Research, 2009. 1259: p. 90-7.
Mao, Y.F., et al., Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats. Biochem Biophys Res Commun, 2009. 381(4): p. 602-5.
Kuroki, C., et al., Neuroprotective Effects of Hydrogen Gas on Brain in Ischemia-Reperfusion Model: A P-31-Nmr Study. Journal of Physiological Sciences, 2009. 59: p. 371-371.
Cai, J.M., et al., Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model. Brain Res, 2009. 1256: p. 129-137.
Hayashida, K., et al., Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury. Journal of Cardiac Failure, 2008. 14(7): p. S168-S168.
Hayashida, K., et al., Inhalation of hydrogen gas protects the heart from ischemic reperfusion injury. Journal of the American College of Cardiology, 2008. 51(10): p. A375-A375.
Cai, J., et al., Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci Lett, 2008. 441(2): p. 167-172.
Fukuda, K., et al., Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress. Biochem Biophys Res Commun, 2007. 361(3): p. 670-674.
