Research studies have shown the potential benefits of hydrogen-rich treatments in protecting various sensory organs from damage caused by oxidative stress and other harmful factors. For instance, studies have demonstrated the protective effects of hydrogen-saturated saline on hearing loss induced by narrow band noise in guinea pigs and its antioxidant properties. Additionally, hydrogen-rich saline has been found to protect against retinal damage induced by blue light and hyperoxia, as well as to attenuate retinopathy and promote the survival of retinal ganglion cells in different animal models. Furthermore, hydrogen therapy has shown promise in preventing noise-induced hearing loss by reducing reactive oxygen species and in protecting auditory and vestibular hair cells from free radicals. For an in-depth exploration read more about these findings below highlighting the potential therapeutic applications of hydrogen in mitigating oxidative stress-related damage to sensory organs such as the ears and eyes.
114.Chen, L., et al., Hydrogen-Saturated Saline Protects Intensive Narrow Band Noise-Induced Hearing Loss in Guinea Pigs through an Antioxidant Effect. PLoS One, 2014. 9(6): p. e100774.
115.Feng, M., et al., Protective effect of saturated hydrogen saline against blue light-induced retinal damage in rats. Int J Ophthalmol, 2012. 5(2): p. 151-7.
116.Huang, L., et al., Hydrogen saline treatment attenuates hyperoxia-induced retinopathy by inhibition of oxidative stress and reduction of VEGF expression. Ophthalmic Res, 2012. 47(3): p. 122-7.
117.Kashiwagi, T., et al., Suppression of glutamate-induced neural cell death by electrolyzed-reduced water, in Animal Cell Technology: Basic & Applied Aspects. 2004, Springer Netherlands. p. 105-109.
118.Kikkawa, Y.S., et al., Hydrogen protects auditory hair cells from free radicals. Neuroreport, 2009. 20(7): p. 689-94.
119.Kurioka, T., et al., Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive oxygen species. Neurosci Res, 2014.
120.Lin, Y., et al., Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs. Neuroscience Letters, 2011. 487(1): p. 12-16.
121.Moossavi, A., F. Bagheri, and H.R. Farkhani, Capabilities of hydrogen Molecules for use in the prevention and treatment in noise induced hearing loss. Rehabilitation Medicine 2014. 2(4).
122.Oharazawa, H., et al., Protection of the Retina by Rapid Diffusion of Hydrogen: Administration of Hydrogen-Loaded Eye Drops in Retinal Ischemia-Reperfusion Injury. Investigative Ophthalmology & Visual Science, 2010. 51(1): p. 487-492.
123.Qu, J., et al., Inhalation of hydrogen gas attenuates ouabain-induced auditory neuropathy in gerbils. Acta Pharmacologica Sinica, 2012. 33(4): p. 445-451.
124.Qu, J., et al., Inhalation of hydrogen gas attenuates cisplatin-induced ototoxicity via reducing oxidative stress. Int J Pediatr Otorhinolaryngol, 2012. 76(1): p. 111-5.
125.Sun, J.C., et al., Hydrogen-rich saline promotes survival of retinal ganglion cells in a rat model of optic nerve crush. PLoS One, 2014. 9(6): p. e99299.
126.Taura, A., et al., Hydrogen protects vestibular hair cells from free radicals. Acta Oto-Laryngologica, 2010. 130: p. 95-100.
127.Tian, L., et al., Hydrogen-rich saline ameliorates the retina against light-induced damage in rats. Med Gas Res, 2013. 3(1): p. 19.
128.Xiao, X., et al., Protective effects of hydrogen saline on diabetic retinopathy in a streptozotocin-induced diabetic rat model. Journal of Ocular Pharmacology and Therapeutics, 2012. 28(1): p. 76-82.
129.Yang, C.X., H. Yan, and T.B. Ding, Hydrogen saline prevents selenite-induced cataract in rats. Molecular Vision, 2013. 19: p. 1684-93.
130.Yokota, T., et al., Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived from nitric oxide in rat retina. Clin Experiment Ophthalmol, 2015.
131.Zhou, Y., et al., Hydrogen-rich saline alleviates experimental noise-induced hearing loss in guinea pigs. Neuroscience, 2012. 209: p. 47-53.
Wu, J., et al., Hydrogen postconditioning promotes survival of rat retinal ganglion cells against ischemia/reperfusion injury through the PI3K/Akt pathway. Biochem Biophys Res Commun, 2018. 495(4): p. 2462-2468.
Ogawa, H., et al., Prevention of ischemia-induced hearing loss by intravenous administration of hydrogen-rich saline in gerbil. Neurosci Lett, 2018. 665: p. 195-199.
Tao, Y., et al., The Comparative Efficiency of Intraperitoneal and Intravitreous Injection of Hydrogen Rich Saline against N-Methyl-N-Nitrosourea Induced Retinal Degeneration: A Topographic Study. Front Pharmacol, 2017. 8: p. 587.
Fransson, A.E., et al., Hydrogen Inhalation Protects against Ototoxicity Induced by Intravenous Cisplatin in the Guinea Pig. Front Cell Neurosci, 2017. 11: p. 280.
Chu, Y.Y., et al., [The protection of hydrogen-rich saline on a rat dry eye model induced by scopolamine hydrobromide]. Zhonghua Yan Ke Za Zhi, 2017. 53(5): p. 363-372.
Chen, L., et al., Molecular mechanisms underlying the protective effects of hydrogen-saturated saline on noise-induced hearing loss. Acta Otolaryngol, 2017: p. 1-6.
Cejka, C., et al., Molecular Hydrogen Effectively Heals Alkali-Injured Cornea via Suppression of Oxidative Stress. Oxid Med Cell Longev, 2017. 2017: p. 8906027.
Wang, R., et al., Postconditioning with inhaled hydrogen promotes survival of retinal ganglion cells in a rat model of retinal ischemia/reperfusion injury. Brain Res, 2016. 1632: p. 82-90.
Igarashi, T., et al., Hydrogen prevents corneal endothelial damage in phacoemulsification cataract surgery. Sci Rep, 2016. 6: p. 31190.
Chen, T., et al., Protective effects of hydrogen-rich saline against N-methyl-N-nitrosourea-induced photoreceptor degeneration. Exp Eye Res, 2016. 148: p. 65-73.
Yokota, T., et al., Protective effect of molecular hydrogen against oxidative stress caused by peroxynitrite derived from nitric oxide in rat retina. Clin Experiment Ophthalmol, 2015.
Qi, L.S., et al., Sirtuin Type 1 Mediates the Retinal Protective Effect of Hydrogen-Rich Saline Against Light-Induced Damage in Rats. Invest Ophthalmol Vis Sci, 2015. 56(13): p. 8268-79.
Sun, J.C., et al., Hydrogen-rich saline promotes survival of retinal ganglion cells in a rat model of optic nerve crush. PLoS One, 2014. 9(6): p. e99299.
Moossavi, A., F. Bagheri, and H.R. Farkhani, Capabilities of hydrogen Molecules for use in the prevention and treatment in noise induced hearing loss. Rehabilitation Medicine 2014. 2(4).
Kurioka, T., et al., Inhaled hydrogen gas therapy for prevention of noise-induced hearing loss through reducing reactive oxygen species. Neurosci Res, 2014.
Chen, L., et al., Hydrogen-Saturated Saline Protects Intensive Narrow Band Noise-Induced Hearing Loss in Guinea Pigs through an Antioxidant Effect. PLoS One, 2014. 9(6): p. e100774.
Yang, C.X., H. Yan, and T.B. Ding, Hydrogen saline prevents selenite-induced cataract in rats. Molecular Vision, 2013. 19: p. 1684-93.
Tian, L., et al., Hydrogen-rich saline ameliorates the retina against light-induced damage in rats. Med Gas Res, 2013. 3(1): p. 19.
Zhou, Y., et al., Hydrogen-rich saline alleviates experimental noise-induced hearing loss in guinea pigs. Neuroscience, 2012. 209: p. 47-53.
Xiao, X., et al., Protective effects of hydrogen saline on diabetic retinopathy in a streptozotocin-induced diabetic rat model. Journal of Ocular Pharmacology and Therapeutics, 2012. 28(1): p. 76-82.
Qu, J., et al., Inhalation of hydrogen gas attenuates cisplatin-induced ototoxicity via reducing oxidative stress. Int J Pediatr Otorhinolaryngol, 2012. 76(1): p. 111-5.
Qu, J., et al., Inhalation of hydrogen gas attenuates ouabain-induced auditory neuropathy in gerbils. Acta Pharmacologica Sinica, 2012. 33(4): p. 445-451.
Huang, L., et al., Hydrogen saline treatment attenuates hyperoxia-induced retinopathy by inhibition of oxidative stress and reduction of VEGF expression. Ophthalmic Res, 2012. 47(3): p. 122-7.
Feng, M., et al., Protective effect of saturated hydrogen saline against blue light-induced retinal damage in rats. Int J Ophthalmol, 2012. 5(2): p. 151-7.
Lin, Y., et al., Hydrogen in drinking water attenuates noise-induced hearing loss in guinea pigs. Neuroscience Letters, 2011. 487(1): p. 12-16.
Taura, A., et al., Hydrogen protects vestibular hair cells from free radicals. Acta Oto-Laryngologica, 2010. 130: p. 95-100.
Oharazawa, H., et al., Protection of the Retina by Rapid Diffusion of Hydrogen: Administration of Hydrogen-Loaded Eye Drops in Retinal Ischemia-Reperfusion Injury. Investigative Ophthalmology & Visual Science, 2010. 51(1): p. 487-492.
Kikkawa, Y.S., et al., Hydrogen protects auditory hair cells from free radicals. Neuroreport, 2009. 20(7): p. 689-94.
Kashiwagi, T., et al., Suppression of glutamate-induced neural cell death by electrolyzed-reduced water, in Animal Cell Technology: Basic & Applied Aspects. 2004, Springer Netherlands. p. 105-109.
