The research studies below focuses on the potential therapeutic effects of hydrogen-rich solutions, particularly hydrogen gas and hydrogen-rich saline, in various models of lung injury and other conditions. These studies explore the protective effects of hydrogen therapy in conditions such as acute lung injury induced by burn, hemorrhagic shock, ventilator-induced lung injury, and other inflammatory processes. Hydrogen therapy is shown to reduce inflammation, oxidative stress, and apoptosis in lung tissues, thereby potentially mitigating lung damage and improving outcomes in different experimental models. Additionally, some studies investigate the impact of hydrogen therapy on conditions beyond lung injury, such as testicular oxidative stress, acute peritonitis, uveitis, pulmonary fibrosis, and more. The findings suggest that hydrogen therapy may have broad-ranging protective effects in various pathological processes, making it a promising area of research for potential clinical applications.
375.Du, Z., et al., Protective effects of hydrogen-rich saline in uncontrolled hemorrhagic shock. Journal of Surgical Research, 2014. In press.
376.Fang, Y., et al., Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model. Journal of Burn Care and Research, 2011. 32(3): p. e82-91.
377.Haam, S., et al., The effects of hydrogen gas inhalation during ex vivo lung perfusion on donor lungs obtained after cardiac deathdagger. Eur J Cardiothorac Surg, 2015.
378.Huang, C.S., et al., Hydrogen inhalation ameliorates ventilator-induced lung injury. Critical Care, 2010. 14(6): p. R234.
379.Huang, C.S., et al., Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation. Biochemical and Biophysical Research Communications, 2011. 408(2): p. 253-8.
380.Kawamura, T., et al., Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. Am J Physiol Lung Cell Mol Physiol, 2013. 304(10): p. L646-56.
381.Li, S., et al., Long-term treatment of hydrogen-rich saline abates testicular oxidative stress induced by nicotine in mice. J Assist Reprod Genet, 2014. 31(1): p. 109-14.
382.Liang, C., et al., [Effect of hydrogen inhalation on p38 MAPK activation in rats with lipopolysaccharide- induced acute lung injury]. Nan Fang Yi Ke Da Xue Xue Bao, 2012. 32(8): p. 1211-3.
383.Liu, S., et al., Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats. Journal of Biomedicine & Biotechnology, 2011. 2011: p. 305086.
384.Liu, R., et al., Lung inflation with hydrogen during the cold ischemia phase decreases lung graft injury in rats. Exp Biol Med (Maywood), 2015.
385.Liu, S.L., et al., Hydrogen Therapy may be a Novel and Effective Treatment for COPD. Front Pharmacol, 2011. 2: p. 19.
386.Liu, H., et al., Combination therapy with nitric oxide and molecular hydrogen in a murine model of acute lung injury. Shock, 2015. 43(5): p. 504-11.
387.Liu, W., et al., Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury. World J Gastroenterol, 2013. 19(4): p. 492-502.
388.Ning, Y., et al., Attenuation of cigarette smoke-induced airway mucus production by hydrogen-rich saline in rats. PLoS One, 2013. 8(12): p. e83429.
389.Noda, K., et al., Hydrogen Preconditioning During Ex Vivo Lung Perfusion Improves the Quality of Lung Grafts in Rats. Transplantation 2014. ??
390.Qiu, X., et al., Hydrogen inhalation ameliorates lipopolysaccharide-induced acute lung injury in mice. Int Immunopharmacol, 2011. 11(12): p. 2130-7.
391.Qiu, X.C., et al., [Effect of hydrogen-rich saline on blood pressure and antioxidant ability of lung tissue in scalded rats following delayed resuscitation]. Zhonghua Shao Shang Za Zhi, 2010. 26(6): p. 435-8.
392.Sato, C., et al., Effects of hydrogen water on paraquat-induced pulmonary fibrosis in mice. The Kitasato medical journal 2015. 45(1): p. 9-16.
393.Shi, J., et al., Hydrogen saline is protective for acute lung ischaemia/reperfusion injuries in rats. Heart Lung Circ, 2012. 21(9): p. 556-63.
394.Sun, Q.A., et al., Hydrogen-Rich Saline Provides Protection Against Hyperoxic Lung Injury. Journal of Surgical Research, 2011. 165(1): p. E43-E49.
395.Tanaka, Y., et al., Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement. Biochem Biophys Res Commun, 2012. 425(4): p. 873-9.
396.Terasaki, Y., et al., Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. American Journal of Physiology – Lung Cellular and Molecular Physiology, 2011. 301(4): p. L415-26.
397.Tomofuji, T., et al., Effects of hydrogen-rich water on aging periodontal tissues in rats. Sci Rep, 2014. 4: p. 5534.
398.Xiao, M., et al., Hydrogen-rich saline reduces airway remodeling via inactivation of NF-kappaB in a murine model of asthma. Eur Rev Med Pharmacol Sci, 2013. 17(8): p. 1033-43.
399.Xie, K., et al., Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis. Shock, 2012. 37(5): p. 548-55.
400.Zhai, Y., et al., Hydrogen-rich saline ameliorates lung injury associated with cecal ligation and puncture-induced sepsis in rats. Exp Mol Pathol, 2015. 98(2): p. 268-276.
401.Zhang, J., et al., Effect of hydrogen-rich water on acute peritonitis of rat models. Int Immunopharmacol, 2014. 21(1): p. 94-101.
402.Zheng, J., et al., Saturated hydrogen saline protects the lung against oxygen toxicity. Undersea & Hyperbaric Medicine, 2010. 37(3): p. 185-192.
Hydrogen inhalation ameliorates ventilator-induced lung injury
Zhang, G., et al., The Anti-inflammatory Effect of Hydrogen on Lung Transplantation Model of Pulmonary Microvascular Endothelial Cells During Cold Storage Period. Transplantation, 2018. 102(8): p. 1253-1261.
Wu, D., et al., Hydrogen protects against hyperoxia-induced apoptosis in type II alveolar epithelial cells via activation of PI3K/Akt/Foxo3a signaling pathway. Biochem Biophys Res Commun, 2018. 495(2): p. 1620-1627.
Lu, W., et al., Hydrogen gas inhalation protects against cigarette smoke-induced COPD development in mice. J Thorac Dis, 2018. 10(6): p. 3232-3243.
Haam, S., et al., Hydrogen gas inhalation during ex vivo lung perfusion of donor lungs recovered after cardiac death. J Heart Lung Transplant, 2018.
Chen, M., et al., Hydrogen protects lung from hypoxia/re-oxygenation injury by reducing hydroxyl radical production and inhibiting inflammatory responses. Sci Rep, 2018. 8(1): p. 8004.
Zhao, C., et al., Changes in IL-4 and IL-13 expression in allergic-rhinitis treated with hydrogen-rich saline in guinea-pig model. Allergol Immunopathol (Madr), 2017.
Yu, S., et al., Hydrogen-rich saline attenuates eosinophil activation in a guinea pig model of allergic rhinitis via reducing oxidative stress. J Inflamm (Lond), 2017. 14: p. 1.
Ying, Y., et al., Protective effect of hydrogen-saturated saline on acute lung injury induced by oleic acid in rats. J Orthop Surg Res, 2017. 12(1): p. 134.
Yan, W.M., et al., Effects of hydrogen-rich saline on endotoxin-induced uveitis. Med Gas Res, 2017. 7(1): p. 9-18.
Xiao, L. and N. Miwa, Hydrogen-rich water achieves cytoprotection from oxidative stress injury in human gingival fibroblasts in culture or 3D-tissue equivalents, and wound-healing promotion, together with ROS-scavenging and relief from glutathione diminishment. Hum Cell, 2017. 30(2): p. 72-87.
Wang, K., et al., Hydrogen-rich saline prevents the down regulation of claudin-5 protein in septic rat lung via the PI3K/Akt signaling pathway. Int J Clin Exp Med, 2017. 10(8): p. 11717-11727.
Takahashi, M., et al., Immersing lungs in hydrogen-rich saline attenuates lung ischaemia-reperfusion injury. Eur J Cardiothorac Surg, 2017. 51(3): p. 442-448.
Suzuki, Y., et al., Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice. Biochem Biophys Res Commun, 2017. 492(1): p. 74-81.
Liu, Z., et al., Effect of Hydrogen-Rich Saline on Postoperative Intra-Abdominal Adhesion Bands Formation in Mice. Med Sci Monit, 2017. 23: p. 5363-5373.
Liu, X., et al., Hydrogen coadministration slows the development of COPD-like lung disease in a cigarette smoke-induced rat model. Int J Chron Obstruct Pulmon Dis, 2017. 12: p. 1309-1324.
Li, Q., Y. Tanaka, and N. Miwa, Influence of hydrogen-occluding-silica on migration and apoptosis in human esophageal cells in vitro. Med Gas Res, 2017. 7(2): p. 76-85.
Kim, J., H.J. Lee, and S.H. Hong, Inhibition of streptococcal biofilm by hydrogen water. J Dent, 2017. 58: p. 34-39.
He, Y., et al., Effects of Hydrogen Gas Inhalation on Endometriosis in Rats. Reprod Sci, 2017. 24(2): p. 324-331.
Ge, L., et al., Hydrogen-rich saline attenuates spinal cord hemisection-induced testicular injury in rats. Oncotarget, 2017. 8(26): p. 42314-42331.
Dong, W.W., et al., Protective Effects of Hydrogen-Rich Saline Against Lipopolysaccharide-Induced Alveolar Epithelial-to-Mesenchymal Transition and Pulmonary Fibrosis. Med Sci Monit, 2017. 23: p. 2357-2364.
Audi, S.H., et al., Protection by Inhaled Hydrogen Therapy in a Rat Model of Acute Lung Injury can be Tracked in vivo Using Molecular Imaging. Shock, 2017. 48(4): p. 467-476.
Ushida, T., et al., Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model. Free Radic Biol Med, 2016. 101: p. 524-533.
Tao, B., et al., Effects of hydrogen-rich saline on aquaporin 1, 5 in septic rat lungs. J Surg Res, 2016. 202(2): p. 291-8.
Muramatsu, Y., et al., Hydrogen-rich water ameliorates bronchopulmonary dysplasia (BPD) in newborn rats. Pediatr Pulmonol, 2016. 51(9): p. 928-35.
Miyazaki, N., et al., Preventive Effect of Hydrogen Water on the Development of Detrusor Overactivity in a Rat Model of Bladder Outlet Obstruction. J Urol, 2016. 195(3): p. 780-7.
Meng, C., et al., Protection of donor lung inflation in the setting of cold ischemia against ischemia-reperfusion injury with carbon monoxide, hydrogen, or both in rats. Life Sci, 2016. 151: p. 199-206.
Huang, S.L., J. Jiao, and H.W. Yan, Hydrogen-rich saline attenuates steroid-associated femoral head necrosis through inhibition of oxidative stress in a rabbit model. Exp Ther Med, 2016. 11(1): p. 177-182.
Hong, Y., et al., Combination therapy of molecular hydrogen and hyperoxia improves survival rate and organ damage in a zymosan-induced generalized inflammation model. Exp Ther Med, 2016. 11(6): p. 2590-2596.
He, X., et al., Hydrogen-rich Water Exerting a Protective Effect on Ovarian Reserve Function in a Mouse Model of Immune Premature Ovarian Failure Induced by Zona Pellucida Chin Med J (Engl), 2016. 129(19): p. 2331-7.
Hara, F., et al., Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells. Circ J, 2016.
Diao, M., et al., Hydrogen Gas Inhalation Attenuates Seawater Instillation-Induced Acute Lung Injury via the Nrf2 Pathway in Rabbits. Inflammation, 2016.
Chen, S., W. Jiang, and X.H. Wang, Protective Effect of Hydrogen Injected Subcutaneously on Testicular Tissues of Rats Exposed to Cigarette Smoke. West Indian Med J, 2016.
Chen, L., et al., Re: Preventive Effect of Hydrogen Water on the Development of Detrusor Overactivity in a Rat Model of Bladder Outlet Obstruction: N. Miyazaki, O. Yamaguchi, M. Nomiya, K. Aikawa and J. Kimura J Urol 2016;195:780-787. J Urol, 2016. 196(2): p. 620-1.
Zhang, Y., Y. Liu, and J. Zhang, Saturated hydrogen saline attenuates endotoxin-induced lung dysfunction. J Surg Res, 2015. 198(1): p. 41-9.
Zhai, Y., et al., Hydrogen-rich saline ameliorates lung injury associated with cecal ligation and puncture-induced sepsis in rats. Exp Mol Pathol, 2015. 98(2): p. 268-276.
Yuan, L., et al., Administration of hydrogen-rich saline in mice with allogeneic hematopoietic stem-cell transplantation. Med Sci Monit, 2015. 21: p. 749-54.
Wu, Q., et al., Hydrogen water alleviates lung injury induced by one-lung ventilation. J Surg Res, 2015.
Sato, C., et al., Effects of hydrogen water on paraquat-induced pulmonary fibrosis in mice. The Kitasato medical journal 2015. 45(1): p. 9-16.
Nakata, K., et al., Stimulation of human damaged sperm motility with hydrogen molecule. Med Gas Res, 2015. 5(1): p. 2.
Liu, R., et al., Lung inflation with hydrogen during the cold ischemia phase decreases lung graft injury in rats. Exp Biol Med (Maywood), 2015.
Liu, H., et al., Combination therapy with nitric oxide and molecular hydrogen in a murine model of acute lung injury. Shock, 2015. 43(5): p. 504-11.
Kishimoto, Y., et al., Hydrogen ameliorates pulmonary hypertension in rats by anti-inflammatory and antioxidant effects. J Thorac Cardiovasc Surg, 2015. 150(3): p. 645-654 e3.
Hattori, Y., et al., Maternal molecular hydrogen treatment attenuates lipopolysaccharide-induced rat fetal lung injury. Free Radic Res, 2015. 49(8): p. 1026-37.
Haam, S., et al., The effects of hydrogen gas inhalation during ex vivo lung perfusion on donor lungs obtained after cardiac death. Eur J Cardiothorac Surg, 2015. 48(4): p. 542-7.
Guan, Z., et al., Effects of vitamin C, vitamin E, and molecular hydrogen on the placental function in trophoblast cells. Arch Gynecol Obstet, 2015.
Chen, X., et al., Protective Effects of Hydrogen-Rich Saline on Rats with Smoke Inhalation Injury. Oxid Med Cell Longev, 2015. 2015: p. 106836.
Chen, S. and W. Jiang, Effect of hydrogen injected subcutaneously on testicular tissues of rats exposed to cigarette smoke. Int J Clin Exp Med, 2015. 8(4): p. 5565-70.
Zhang, J., et al., Effect of hydrogen-rich water on acute peritonitis of rat models. Int Immunopharmacol, 2014. 21(1): p. 94-101.
Tomofuji, T., et al., Effects of hydrogen-rich water on aging periodontal tissues in rats. Sci Rep, 2014. 4: p. 5534.
Noda, K., et al., Hydrogen Preconditioning During Ex Vivo Lung Perfusion Improves the Quality of Lung Grafts in Rats. Transplantation 2014.
Li, S., et al., Long-term treatment of hydrogen-rich saline abates testicular oxidative stress induced by nicotine in mice. J Assist Reprod Genet, 2014. 31(1): p. 109-14.
Du, Z., et al., Protective effects of hydrogen-rich saline in uncontrolled hemorrhagic shock. Journal of Surgical Research, 2014. In press.
Xiao, M., et al., Hydrogen-rich saline reduces airway remodeling via inactivation of NF-kappaB in a murine model of asthma. Eur Rev Med Pharmacol Sci, 2013. 17(8): p. 1033-43.
Ning, Y., et al., Attenuation of cigarette smoke-induced airway mucus production by hydrogen-rich saline in rats. PLoS One, 2013. 8(12): p. e83429.
Liu, W., et al., Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury. World J Gastroenterol, 2013. 19(4): p. 492-502.
Kawamura, T., et al., Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. Am J Physiol Lung Cell Mol Physiol, 2013. 304(10): p. L646-56.
Xie, K., et al., Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis. Shock, 2012. 37(5): p. 548-55.
Tanaka, Y., et al., Profiling molecular changes induced by hydrogen treatment of lung allografts prior to procurement. Biochem Biophys Res Commun, 2012. 425(4): p. 873-9.
Shi, J., et al., Hydrogen saline is protective for acute lung ischaemia/reperfusion injuries in rats. Heart Lung Circ, 2012. 21(9): p. 556-63.
Liang, C., et al., [Effect of hydrogen inhalation on p38 MAPK activation in rats with lipopolysaccharide- induced acute lung injury]. Nan Fang Yi Ke Da Xue Xue Bao, 2012. 32(8): p. 1211-3.
Terasaki, Y., et al., Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. American Journal of Physiology – Lung Cellular and Molecular Physiology, 2011. 301(4): p. L415-26.
Sun, Q.A., et al., Hydrogen-Rich Saline Provides Protection Against Hyperoxic Lung Injury. Journal of Surgical Research, 2011. 165(1): p. E43-E49.
Qiu, X., et al., Hydrogen inhalation ameliorates lipopolysaccharide-induced acute lung injury in mice. Int Immunopharmacol, 2011. 11(12): p. 2130-7.
Liu, S.L., et al., Hydrogen Therapy may be a Novel and Effective Treatment for COPD. Front Pharmacol, 2011. 2: p. 19.
Liu, S., et al., Consumption of hydrogen water reduces paraquat-induced acute lung injury in rats. Journal of Biomedicine & Biotechnology, 2011. 2011: p. 305086.
Huang, C.S., et al., Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation. Biochemical and Biophysical Research Communications, 2011. 408(2): p. 253-8.
Fang, Y., et al., Hydrogen-rich saline protects against acute lung injury induced by extensive burn in rat model. Journal of Burn Care and Research, 2011. 32(3): p. e82-91.
Zheng, J., et al., Saturated hydrogen saline protects the lung against oxygen toxicity. Undersea & Hyperbaric Medicine, 2010. 37(3): p. 185-192.
Qiu, X.C., et al., [Effect of hydrogen-rich saline on blood pressure and antioxidant ability of lung tissue in scalded rats following delayed resuscitation]. Zhonghua Shao Shang Za Zhi, 2010. 26(6): p. 435-8.
Huang, C.S., et al., Hydrogen inhalation ameliorates ventilator-induced lung injury. Critical Care, 2010. 14(6): p. R234.
